{"text_format":"1","workbook":"xlsx","n_sheets":16,"sheets":["Accueil","HELP","KPTIVA","OFA","Calculator","DRUGS","Ket","Propofol","Sufenta","Rapifen","Remi","KetOFA","ProFA","Dexmed","LIDO","YourDrug"],"not_rendered":{"charts":4,"images":11,"macros":1,"external_links":0,"defined_names":534,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Accueil","index":0,"n_rows":22,"n_cols":11,"rows_kept":22,"cut":false,"hidden":false,"merged":[[2,10,2,14],[11,1,13,7],[17,2,17,3],[18,2,18,3],[21,4,21,5]]}
[]
[]
[null,null,null,null,null,null,null,null,null,null,"To run EskeTiva, You must ENABLE macros in Excel"]
[]
[null,null,null,null,null,null,null,null,null,null,"1. Select the File tab and choose Options."]
[null,null,null,null,null,null,null,null,null,null,"2. Select Trust Center, and then choose Trust Center Settings."]
[null,null,null,null,null,null,null,null,null,null,"3. In the Trust Center, select Macro Settings."]
[]
[]
[]
[]
[null,"KPTiva release 2.00. Georges Mion ©  2026"]
[]
[]
[]
[]
[]
[null,null,"if macros are"]
[null,null,"already enabled"]
[]
[]
[null,null,null,null,"OR"]

{"sheet":"HELP","index":1,"n_rows":55,"n_cols":18,"rows_kept":55,"cut":false,"hidden":false,"merged":[[3,16,3,23],[5,16,5,23],[12,3,12,9],[13,3,13,9],[54,6,54,7],[17,1,17,11],[4,3,6,9],[10,1,10,11],[15,1,15,11],[8,2,8,10],[11,3,11,7],[11,8,11,9]]}
[]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Enable macros!"]
[null,null,null,"KPTiva release 2.00. Georges Mion ©  2025"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Use the correct decimal separator!"]
[]
[]
[null,null,"Before starting KPTiva (Ketamine Propofol Total intravenous anesthesia)",null,null,null,null,null,null,null,null,null,null,null,null,"Zoom value"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,115,null,"You can use this control to adjust the zoom"]
[null,"KPTiva simulates hypnotics and narcotics plasmatic concentrations after IV administration (bolus or infusion)"]
[null,null,null,"Calculations mirror those of RUGLOOP",null,null,null,null,"DEMED Models downloads"]
[null,null,null,"Like RUGLOOP/DEMED models, KPTIVA is for educational purpose, "]
[null,null,null,"and should NOT be used for therapeutic management"]
[]
[null,"BEWARE: KPTiva has been written with Microsoft Excel 2016.  "]
[]
[null,"With another software, malfunction may affect macrocommands. Unfortunately, Excel viewer cannot run macros"]
[]
[]
[]
[null,"STEPS",1,"First, enter patient weight, height, age and gender (M=1, F=2)"]
[null,null,null,"You are in Excel environment: do not forget to press the \"enter\" key !"]
[]
[null,null,2,"Check drug concentration"]
[null,null,null,"You can convert mg, mL, mg/kg, mg/kg/h, µg/kg/min with the calculator"]
[]
[null,null,3,"Time is displayed as minutes (zero cannot be changed)"]
[]
[null,null,4,"You may inject selected drug either as IV boluses, or infusions"]
[]
[null,null,5,"Be careful with the parameters units (they are indicated: for alfentanil, bolus in mg)"]
[]
[null,null,6,"To stop an infusion, you must enter a \"zero\" value at the time (min) it is stopped"]
[null,null,null,"Infused volume is the incremental quantity of administered solution (depends on drug concentration)"]
[]
[null,null,null,null,null,"The spreadsheet gives a view of your decisions: boluses and infusions (Color assigned to the drug)"]
[null,null,null,null,null,"The control panel displays plasmatic drug concentrations (µg or ng/mL)"]
[]
[null,null,null,null,null,"Plasmatic concentration within usual action range displays the color assigned to the drug"]
[]
[null,null,null,null,null,"If concentration exceeds the usual value, background color turns to red (black for Dexmed)"]
[]
[null,null,7,"BEWARE: It is advised to erase all entered data between each simulation (New simulation) "]
[]
[]
[]
[null,"OFA",null,"If you choose the OFA page, you can simulate YOUR OWN DRUG PK"]
[]
[null,null,null,"You will be asked to enter the A, B, C and  a,b, or g constants of the PK model"]
[null,null,null,"and, of course, the dose of the drug used to build the model."]
[]
[null,null,null,"ENJOY !"]
[]
[null,null,null,null,null,"GM","georgesmion.com"]

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[]
[]
[]
[]
[]
[null,null,null,null,"zoom value:",null,101]
[]
[]
[]
[]
[]
[null,"PATIENT"]
[]
[null,null,"Age",null,40,"years"]
[]
[null,null,"Weight",null,70,"Kg"]
[]
[null,null,"Height",null,170,"cm"]
[]
[null,null,"BMI",null,{"$f":"10000*Poids/(E18*E18)","v":24.221453287197232}]
[]
[null,null,"Gender",null,1,"M=1   F=2"]
[]
[]
[null,null,null,null,null,null,"TIME",null,"(Min)","To",5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300,null,null,null,"BORNES VALIDATION"]
[null,null,null,null,null,"Ketamine",null,null,"Bolus",null,null,null,20]
[null,null,null,null,null,null,null,null,"Infusion",null,null,0.3]
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[null,"         C o n c e n t r a t i o n   C o n c e n t r a t i o n   C o n c e n t r a t i o n   ",10,"Ketamine",null,null,null,null,"Bolus mg",0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,300,"bolus mg"]
[null,null,null,"mg/kg/h",null,null,null,null,"Infusion",0,{"$f":"J30","v":0},{"$f":"K30","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,null,null,0,5,"mg/kg/h",null,null,"mise en forme conditionnelle Cp"]
[null,null,null,"µg/kg/min",null,null,null,null,"Infusion",0,{"$f":"J31","v":0},{"$f":"K31","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BR31","v":0},null,null,0,12,"µg/kg/min"]
[null,null,"   Scale",null,null,null,"mL",null,"Volume",0,{"$f":"J32 + (K29/Concentration_Ketamine) + (    (5*K30*Poids)/(60*Concentration_Ketamine)      ) + (       (5*K31*Poids)/(1000*Concentration_Ketamine)        )","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"AP32 + (AQ29/Concentration_Ketamine) + (    (5*AQ30*Poids)/(60*Concentration_Ketamine)      ) + (       (5*AQ31*Poids)/(1000*Concentration_Ketamine)        )","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,"Labels",null,"ng/mL",null,"Cp",0,{"$f":"Ket!W108*1000","v":0},{"$f":"Ket!X108*1000","v":0},{"$f":"Ket!Y108*1000","v":0},{"$f":"Ket!Z108*1000","v":0},{"$f":"Ket!AA108*1000","v":0},{"$f":"Ket!AB108*1000","v":0},{"$f":"Ket!AC108*1000","v":0},{"$f":"Ket!AD108*1000","v":0},{"$f":"Ket!AE108*1000","v":0},{"$f":"Ket!AF108*1000","v":0},{"$f":"Ket!AG108*1000","v":0},{"$f":"Ket!AH108*1000","v":0},{"$f":"Ket!AI108*1000","v":0},{"$f":"Ket!AJ108*1000","v":0},{"$f":"Ket!AK108*1000","v":0},{"$f":"Ket!AL108*1000","v":0},{"$f":"Ket!AM108*1000","v":0},{"$f":"Ket!AN108*1000","v":0},{"$f":"Ket!AO108*1000","v":0},{"$f":"Ket!AP108*1000","v":0},{"$f":"Ket!AQ108*1000","v":0},{"$f":"Ket!AR108*1000","v":0},{"$f":"Ket!AS108*1000","v":0},{"$f":"Ket!AT108*1000","v":0},{"$f":"Ket!AU108*1000","v":0},{"$f":"Ket!AV108*1000","v":0},{"$f":"Ket!AW108*1000","v":0},{"$f":"Ket!AX108*1000","v":0},{"$f":"Ket!AY108*1000","v":0},{"$f":"Ket!AZ108*1000","v":0},{"$f":"Ket!BA108*1000","v":0},{"$f":"Ket!BB108*1000","v":0},{"$f":"Ket!BC108*1000","v":0},{"$f":"Ket!BD108*1000","v":0},{"$f":"Ket!BE108*1000","v":0},{"$f":"Ket!BF108*1000","v":0},{"$f":"Ket!BG108*1000","v":0},{"$f":"Ket!BH108*1000","v":0},{"$f":"Ket!BI108*1000","v":0},{"$f":"Ket!BJ108*1000","v":0},{"$f":"Ket!BK108*1000","v":0},{"$f":"Ket!BL108*1000","v":0},{"$f":"Ket!BM108*1000","v":0},{"$f":"Ket!BN108*1000","v":0},{"$f":"Ket!BO108*1000","v":0},{"$f":"Ket!BP108*1000","v":0},{"$f":"Ket!BQ108*1000","v":0},{"$f":"Ket!BR108*1000","v":0},{"$f":"Ket!BS108*1000","v":0},{"$f":"Ket!BT108*1000","v":0},{"$f":"Ket!BU108*1000","v":0},{"$f":"Ket!BV108*1000","v":0},{"$f":"Ket!BW108*1000","v":0},{"$f":"Ket!BX108*1000","v":0},{"$f":"Ket!BY108*1000","v":0},{"$f":"Ket!BZ108*1000","v":0},{"$f":"Ket!CA108*1000","v":0},{"$f":"Ket!CB108*1000","v":0},{"$f":"Ket!CC108*1000","v":0},{"$f":"Ket!CD108*1000","v":0},null,null,null,null,null,null,"Ketamine","ng/mL",null,1,21,101,401,701,1001,3001]
[]
[null,null,10,"Propofol",null,null,null,null,"Bolus mg",0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,600,"bolus mg"]
[null,null,null,"mg/kg/h",null,null,null,null,"Infusion",0,{"$f":"J36","v":0},{"$f":"K36","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,null,null,0,20,"mg/kg/h"]
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[null,null,"   Scale",null,"Labels",null,"µg/mL",null,"Cp",0,{"$f":"Propofol!W113","v":0},{"$f":"Propofol!X113","v":0},{"$f":"Propofol!Y113","v":0},{"$f":"Propofol!Z113","v":0},{"$f":"Propofol!AA113","v":0},{"$f":"Propofol!AB113","v":0},{"$f":"Propofol!AC113","v":0},{"$f":"Propofol!AD113","v":0},{"$f":"Propofol!AE113","v":0},{"$f":"Propofol!AF113","v":0},{"$f":"Propofol!AG113","v":0},{"$f":"Propofol!AH113","v":0},{"$f":"Propofol!AI113","v":0},{"$f":"Propofol!AJ113","v":0},{"$f":"Propofol!AK113","v":0},{"$f":"Propofol!AL113","v":0},{"$f":"Propofol!AM113","v":0},{"$f":"Propofol!AN113","v":0},{"$f":"Propofol!AO113","v":0},{"$f":"Propofol!AP113","v":0},{"$f":"Propofol!AQ113","v":0},{"$f":"Propofol!AR113","v":0},{"$f":"Propofol!AS113","v":0},{"$f":"Propofol!AT113","v":0},{"$f":"Propofol!AU113","v":0},{"$f":"Propofol!AV113","v":0},{"$f":"Propofol!AW113","v":0},{"$f":"Propofol!AX113","v":0},{"$f":"Propofol!AY113","v":0},{"$f":"Propofol!AZ113","v":0},{"$f":"Propofol!BA113","v":0},{"$f":"Propofol!BB113","v":0},{"$f":"Propofol!BC113","v":0},{"$f":"Propofol!BD113","v":0},{"$f":"Propofol!BE113","v":0},{"$f":"Propofol!BF113","v":0},{"$f":"Propofol!BG113","v":0},{"$f":"Propofol!BH113","v":0},{"$f":"Propofol!BI113","v":0},{"$f":"Propofol!BJ113","v":0},{"$f":"Propofol!BK113","v":0},{"$f":"Propofol!BL113","v":0},{"$f":"Propofol!BM113","v":0},{"$f":"Propofol!BN113","v":0},{"$f":"Propofol!BO113","v":0},{"$f":"Propofol!BP113","v":0},{"$f":"Propofol!BQ113","v":0},{"$f":"Propofol!BR113","v":0},{"$f":"Propofol!BS113","v":0},{"$f":"Propofol!BT113","v":0},{"$f":"Propofol!BU113","v":0},{"$f":"Propofol!BV113","v":0},{"$f":"Propofol!BW113","v":0},{"$f":"Propofol!BX113","v":0},{"$f":"Propofol!BY113","v":0},{"$f":"Propofol!BZ113","v":0},{"$f":"Propofol!CA113","v":0},{"$f":"Propofol!CB113","v":0},{"$f":"Propofol!CC113","v":0},{"$f":"Propofol!CD113","v":0},null,null,null,null,null,null,"Propofol","µg/mL",null,1,4.0999999999999996,6.1,"µg/mL"]
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[]
[null,null,5,"Sufentanil",null,null,null,null,"Bolus µg",0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,50,"bolus µg"]
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[null,null,null,null,null,null,null,null,null,{"$f":"J51","v":0},{"$f":"(((((((((((K51)*($G$72))*($G$72))*($G$72))*($G$72))*($G$72))*($G$72))*($G$72))/($G$72))/($G$72))/($G$72))/($G$72)","v":0},{"$f":"(((((((((((L51)*($G$72))*($G$72))*($G$72))*($G$72))*($G$72))*($G$72))*($G$72))/($G$72))/($G$72))/($G$72))/($G$72)","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,null,null,null,null,null,{"$f":"(J64)*10","v":0},"_0",153,255]
[null,"Your Drug",null,null,null,"Coeff",{"$f":"$G$72","v":2},null,"Cp (y)",{"$f":"J56","v":0},{"$f":"K56","v":0},{"$f":"L56","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,null,null,null,null,null,{"$f":"(((J69)*10)*10)*10","v":0}]
[null,null,null,null,null,null,null,null,null,{"$f":"J57","v":0},{"$f":"K57","v":0},{"$f":"L57","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,null,null,null,null,null,{"$f":"(((J70)*10)*10)*10","v":0},"_0",255,255]
[]
[null,null,null,null,null,"COEFF",2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,142,169,219]

{"sheet":"Calculator","index":4,"n_rows":27,"n_cols":17,"rows_kept":27,"cut":false,"hidden":false,"merged":[[2,8,2,12],[4,4,4,16],[6,4,6,5],[20,4,20,6],[28,4,28,6],[28,8,28,12],[21,8,21,14],[24,8,24,14]]}
[]
[]
[null,null,null,null,null,null,null,null,"KPTiva CALCULATOR"]
[]
[null,null,null,null,"Enter data in yellow cells and read the equivalent values in the right appropriated colomn"]
[]
[null,null,null,null,"Weight =",null,{"$f":"Poids","v":70},"Kg"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"BOLUS"]
[null,null,null,null,null,null,null,null,null,"mg/kg","mg",null,"mg","mg/kg"]
[null,null,null,null,null,null,null,null,null,null,{"$f":"Poids*J11","v":0},null,null,{"$f":"M11/G7","v":0}]
[]
[null,null,null,null,null,null,null,null,null,null,null,"INFUSION"]
[null,null,null,null,null,null,"Speed",null,"Unit","mg/kg/h","µg/kg/min","µg/min","mg/min","mg/h"]
[null,null,null,null,null,null,null,null,"mg/kg/h",".",{"$f":"(G15*1000)/60","v":0},{"$f":"(G15*Poids*1000)/60","v":0},{"$f":"L15/1000","v":0},{"$f":"M15*60","v":0}]
[null,null,null,null,null,null,null,null,"µg/kg/min",{"$f":"(G16*60)/(1000)","v":0},".",{"$f":"G7*G16","v":0},{"$f":"L16/1000","v":0},{"$f":"M16*60","v":0}]
[]
[]
[null,null,null,null,null,null,null,null,"Ketamine","Propofol","Sufentanil","Alfentanil","Remifentanil","Dexmed","Lidocaine"]
[]
[null,null,null,null,"Concentration",null,null,null,{"$f":"Concentration_Ketamine","v":10},{"$f":"Concentration_propofol","v":10},{"$f":"Concentration_Sufenta","v":5},{"$f":"Concentration_Rapifen","v":100},{"$f":"Concentration_Remi","v":50},{"$f":"OFA!Concentration_Sufenta","v":10},{"$f":"OFA!Concentration_Rapifen","v":10}]
[null,null,null,null,null,null,null,null,"Convert mg into mL"]
[]
[null,null,null,null,null,null,"mg",null,{"$f":"$E$24/I21","v":0},{"$f":"$E$24/J21","v":0},{"$f":"$E$24*1000/K21","v":0},{"$f":"$E$24*1000/L21","v":0},{"$f":"$E$24*1000/M21","v":0},{"$f":"$E$24*1000/N21","v":0},{"$f":"$E$24/O21","v":0},null,"mL"]
[null,null,null,null,null,null,null,null,"Convert mL into mg"]
[]
[null,null,null,null,null,null,"mL",null,{"$f":"$E$27*I21","v":0},{"$f":"$E$27*J21","v":0},{"$f":"$E$27*K21/1000","v":0},{"$f":"$E$27*L21/1000","v":0},{"$f":"$E$27*M21/1000","v":0},{"$f":"$E$27*N21/1000","v":0},{"$f":"$E$27*O21","v":0},null,"mg"]

{"sheet":"DRUGS","index":5,"n_rows":29,"n_cols":50,"rows_kept":29,"cut":false,"hidden":false,"merged":[[28,8,28,14],[27,19,27,33],[28,19,28,33],[26,21,26,31],[26,8,26,14],[4,7,4,16],[8,2,8,4],[6,11,6,12],[6,9,6,10],[6,14,6,15],[4,39,4,49],[6,39,6,47],[6,21,6,25],[6,27,6,31],[4,21,4,31]]}
[]
[]
[]
[]
[null,null,null,null,null,null,null,"Common therapeutic ranges (from light sedation to deep anesthesia)",null,null,null,null,null,null,null,null,null,null,null,null,null,"PKPD    Multi - Exponential models",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PKPD     Compartmental models"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"A",null,"B",null,"C",null,"Alpha",null,"Beta",null,"Gamma",null,"dose",null,null,null,null,null,"K10",null,"K12",null,"K13",null,"K21",null,"K31",null,"Vc"]
[null,null,null,null,null,null,null,null,null,"BOLUS",null,"INFUSION",null,null,"Cp",null,null,null,null,"Model",null,"U/mL",null,null,null,null,null,"min-1",null,null,null,null,null,"mg/kg",null,null,null,"Model",null,"L/min",null,null,null,null,null,null,null,null,null,"L"]
[]
[null,null,"Ketamine:  Cp / effect",null,null,null,null,null,"Ketamine","0.05-2","mg/kg","0.15-1","mg/kg/h",null,"20-1000","ng/mL",null,null,null,"Domino",null,14300,null,2340,null,197,null,81.099999999999994,null,5.71,null,0.22700000000000001,null,2,null,null,null,"Domino",null,0.438,null,0.59199999999999997,null,0.59,null,0.247,null,1.46E-2,null,{"$f":"Ket!E74","v":4.41}]
[]
[null,null,null,"ng/mL","Corresponding effect",null,null,null,"Propofol","0.5-4","mg/kg"," 3-12","mg/kg/h",null," 1-10","µg/mL",null,null,null,"Clements",null,108,null,39,null,0,null,3.9399999999999998E-2,null,3.8E-3,null,0,null,0.25,null,null,null,"Schnider",null,{"$f":"Propofol!K79","v":0.3836381611468116},null,{"$f":"Propofol!K80","v":0.37517564402810311},null,{"$f":"Propofol!K81","v":0.19578454332552694},null,{"$f":"Propofol!K82","v":6.6797314764624957E-2},null,{"$f":"Propofol!K83","v":3.5126050420168065E-3},null,{"$f":"Propofol!K78","v":4.2699999999999996}]
[null,null,1,"0-20","None"]
[null,null,21,"20-100","Anti-hyperalgesic",null,null,null,"Sufentanil","0.05-0.5","µg/kg","0.1-0.6","µg/kg/h",null,"0.1-0.6","ng/mL",null,null,null,"Gepts",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Gepts",null,6.4500000000000002E-2,null,0.1086,null,2.29E-2,null,2.4500000000000001E-2,null,1.2999999999999999E-3,null,{"$f":"Sufenta!K78","v":14.3}]
[null,null,151,"100-300","Analgesic"]
[null,null,401,"300-700","Psychedelic",null,null,null,"Alfentanil","2.5-50","µg/kg","0.15-1","µg/kg/min",null,"50-150","ng/mL",null,null,null,"Shafer",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Shafer",null,7.4800000000000005E-2,null,0.51500000000000001,null,0.23100000000000001,null,0.14199999999999999,null,1.8499999999999999E-2,null,{"$f":"Rapifen!K78","v":1.4930089364464298}]
[null,null,701,"700-1000","Emergence"]
[null,null,1001,"> 1000","Narcosis",null,null,null,"Remifentanil","0.5-2","µg/kg","0.05-0.4","µg/kg/min",null," 2-10","ng/mL",null,null,null,"Minto",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Minto",null,{"$f":"Remi!K79","v":0.5087809406442303},null,{"$f":"Remi!K80","v":0.40027917183526429},null,{"$f":"Remi!K81","v":1.4839618077795165E-2},null,{"$f":"Remi!K82","v":0.20807665453339833},null,{"$f":"Remi!K83","v":1.4022140221402213E-2},null,{"$f":"Remi!K78","v":5.1214256055363316}]
[null,null,2201,"> 2200","Excessive"]
[null,null,null,null,null,null,null,null,"Dexmed","0.5-1","µg/kg","0.1-1","µg/kg/h",null," 0.35-6","ng/mL",null,null,null,"Dyck",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Dyck",null,{"$f":"Dexmed!K79","v":4.2377972465581976E-2},null,{"$f":"Dexmed!K80","v":0.28285356695869834},null,{"$f":"Dexmed!K81","v":0.2490613266583229},null,{"$f":"Dexmed!K82","v":0.16376811594202897},null,{"$f":"Dexmed!K83","v":1.0641711229946524E-2},null,{"$f":"Dexmed!K78","v":7.99}]
[]
[null,null,null,null,null,null,null,null,"Lidocaine",1.5,"mg/kg","1.3-2","mg/kg/h",null,3,"µg/mL",null,null,null,"Schnider",null,8.77,null,1.1399999999999999,null,0,null,0.89500000000000002,null,3.09E-2,null,0,null,1,null,null,null,"Schnider",null,0.21299999999999999,null,0.58299999999999996,null,null,null,0.13,null,null,null,{"$f":"_V1","v":6.0600000000000005}]
[]
[]
[null,null,null,null,null,null,null,null,"KPTiva uses the Domino model for ketamine concentrations.",null,null,null,null,null,null,null,null,null,null,"Your Drug",null,108,null,39,null,0,null,3.9399999999999998E-2,null,3.8E-3,null,0,null,0.25]
[null,null,null,null,null,null,null,null,"If you prefer the Clements model, enter the constants in \"your drug\""]
[]
[null,null,null,null,null,null,null,null,"Clements JA, Nimmo WS. Br J Anaesth. 1981;53(1):27-30."]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"For your own drug, be sure to indicate the dose (mg/kg) used to establish the model"]
[null,null,null,null,null,null,null,null,"Domino EF et al. Anesth Analg. 1982;61(2):87-92.",null,null,null,null,null,null,null,null,null,null,"(by default, I copied the constants from Clements' ketamine model)"]

{"sheet":"Ket","index":6,"n_rows":121,"n_cols":82,"rows_kept":121,"cut":false,"hidden":true,"merged":[[91,0,91,1],[85,0,85,1],[86,0,86,1],[87,0,87,1],[88,0,88,1],[89,0,89,1],[90,0,90,1],[33,0,33,1],[33,2,35,14],[36,2,38,14],[80,0,80,1],[42,2,44,14],[45,2,47,14],[48,2,50,14],[51,2,53,14],[58,2,58,3],[59,2,59,3],[60,2,60,3],[61,2,61,3],[62,2,62,3],[63,2,63,3],[70,0,70,1],[39,2,41,14],[28,4,28,7],[28,11,28,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[27,4,27,7],[27,11,27,12],[11,0,12,14],[14,0,15,14],[19,0,19,14],[20,4,20,7],[21,4,21,7],[21,11,21,12],[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 004",null,null,null,null,"Revision",null,1]
[]
["Rugloop II© Ketamine calculations validation"]
["Drug model:  Domino et al"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Domino et al.: Clin. Pharmacol Ther 1991, 36, 645-653"]
[]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2002-07-18"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for ketamine. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
[null,null,"Unit of concentration : µg/ml"]
[null,null,"Vc = 0.063*mass"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Patient data"]
[]
["Enter patient weight ",null,null,null,null,{"$f":"Poids","v":70},"kg"]
["Enter drug conc",null,null,null,null,{"$f":"Concentration_Ketamine","v":10},"mg/ml"]
[]
[]
[null,null,null,"Vc",{"$f":"0.063*F70","v":4.41}]
[null,null,null,"K10",0.438,"1/min"]
[null,null,null,"K12",{"$f":" 0.592","v":0.59199999999999997},"1/min"]
[null,null,null,"K13",{"$f":" 0.59","v":0.59},"1/min"]
[null,null,null,"K21",0.247,"1/min"]
[null,null,null,"K31",1.46E-2,"1/min"]
[]
["Drug conc[mg/ml]",null,{"$f":"F71","v":10}]
[]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation"]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"E74","v":4.41},"a0",{"$f":"K_K10*K_K21*K_K31","v":7.3125722222222229E-9},{"$f":"K_K10*K_K21","v":3.0051666666666669E-5},"_","PCoef1",{"$f":"(K_K21-K_Lambda1)*(K_K31-K_Lambda1)/(K_Lambda1-K_Lambda2)/(K_Lambda1-K_Lambda3)/K_PK_Vc/K_Lambda1","v":7.375531804284214},{"$f":"(K_K21-K_Lambda1)/(K_Lambda2-K_Lambda1)/K_PK_Vc/K_Lambda1","v":7.4124358256815031},{"$f":"1/K_PK_Vc/K_Lambda1","v":7.891617227091329}]
["K10",null,{"$f":"E75/60","v":7.3000000000000001E-3},"a1",{"$f":"K_K10*K_K31+K_K21*K_K31+K_K21*K_K13+K_K10*K_K21+K_K31*K_K12","v":7.5711166666666681E-5},{"$f":"(K_K10+K_K12+K_K21)","v":2.1283333333333335E-2},"_","PCoef2",{"$f":"(K_K21-K_Lambda2)*(K_K31-K_Lambda2)/(K_Lambda2-K_Lambda1)/(K_Lambda2-K_Lambda3)/K_PK_Vc/K_Lambda2","v":5.1318137352469835},{"$f":"(K_K21-K_Lambda2)/(K_Lambda1-K_Lambda2)/K_PK_Vc/K_Lambda2","v":5.4524038311465635},0]
["K12",null,{"$f":"E76/60","v":9.8666666666666659E-3},"a2",{"$f":"K_K10+K_K12+K_K13+K_K31+K_K21","v":3.1359999999999999E-2},"_","_","PCoef3",{"$f":"(K_K21-K_Lambda3)*(K_K31-K_Lambda3)/(K_Lambda3-K_Lambda2)/(K_Lambda3-K_Lambda1)/K_PK_Vc/K_Lambda3","v":18.555307832318086},0,0]
["K13",null,{"$f":"E77/60","v":9.8333333333333328E-3},"p",{"$f":"K_a1-(K_a2*K_a2/3)","v":-2.5210536666666662E-4},"_","_"]
["K21",null,{"$f":"E78/60","v":4.1166666666666669E-3},"q",{"$f":"(2*K_a2*K_a2*K_a2/27)-(K_a1*K_a2/3)+K_a0","v":1.5003955067407405E-6},"_","_"]
["K31",null,{"$f":"E79/60","v":2.4333333333333333E-4},"r1",{"$f":"SQRT(-(K_p*K_p*K_p)/27)","v":7.703556179473801E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"Ctrl F3",null,"permet de renommer tous les noms d'une feuille"]
[null,null,null,null,null,null,null,null,null,"Modelling results "]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-K_q/2)/K_r1,-1),1)))/3","v":0.97077492325387194},"_","_",null,null,"Lambda1",{"$f":"IF(K_K31>0,E98,IF(K_K21>0,F98,G98))","v":2.8733954408745453E-2}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(K_r1)/3)","v":1.8334134527947837E-2},"_","_",null,null,"Lambda2",{"$f":"IF(K_K31>0,E99,IF(K_K21>0,F99,G99))","v":2.5252671973736273E-3}]
["L1",{"$f":"(POWER(-E95,3)+POWER(E95,2)*K_a2-E95*K_a1+K_a0)<0.000000000000001","v":true},{"$f":"POWER(F95,2)-K__a1*F95+K__a0","v":0},"L1",{"$f":"-(COS(K_Phi)*K_r1_Use-K_a2/3)","v":1.0077839388092369E-4},{"$f":"-(-K__a1+SQRT(K__a1*K__a1-4*K__a0))/2","v":1.5206249072086068E-3},{"$f":"K_K10","v":7.3000000000000001E-3},null,null,"Lambda3",{"$f":"IF(K_K31>0,E100,IF(K_K21>0,F100,G100))","v":1.0077839388092369E-4}]
["L2",{"$f":"(POWER(-E96,3)+POWER(E96,2)*K_a2-E96*K_a1+K_a0)<0.000000000000001","v":true},{"$f":"POWER(F96,2)-F96*K__a1+K__a0","v":0},"L2",{"$f":"-(COS(K_Phi+PI()*2/3)*K_r1_Use-K_a2/3)","v":2.8733954408745453E-2},{"$f":"-(-K__a1-SQRT(K__a1*K__a1-4*K__a0))/2","v":1.976270842612473E-2},0]
["L3",{"$f":"(POWER(-E97,3)+POWER(E97,2)*K_a2-E97*K_a1+K_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(K_Phi+PI()*4/3)*K_r1_Use-K_a2/3)","v":2.5252671973736273E-3},0,0,null,null,"PCoef1",{"$f":"IF(K_K31>0,I86,IF(K_K21>0,J86,K86))","v":7.375531804284214},null,null,null,null,null,null,null,null,null,null,"Colonne des zéros"]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E95,E96),E97)","v":2.8733954408745453E-2},{"$f":"MAX(MAX(F95,F96),F97)","v":1.976270842612473E-2},{"$f":"MAX(MAX(G95,G96),G97)","v":7.3000000000000001E-3},null,null,"PCoef2",{"$f":"IF(K_K31>0,I87,IF(K_K21>0,J87,K87))","v":5.1318137352469835}]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E98<>E95,E100<>E95),E95,IF(AND(E98<>E96,E100<>E96),E96,E97))","v":2.5252671973736273E-3},{"$f":"IF(AND(F98<>F95,F100<>F95),F95,IF(AND(F98<>F96,F100<>F96),F96,F97))","v":1.5206249072086068E-3},{"$f":"IF(AND(G98<>G95,G100<>G95),G95,IF(AND(G98<>G96,G100<>G96),G96,G97))","v":0},null,null,"PCoef3",{"$f":"IF(K_K31>0,I88,IF(K_K21>0,J88,K88))","v":18.555307832318086},null,null,null,null,null,null,null,null,null,null,"Colonne liée à la première ligne de formules"]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E95,E96),E97)","v":1.0077839388092369E-4},{"$f":"MIN(MIN(F95,F96),F97)","v":0},{"$f":"MIN(MIN(G95,G96),G97)","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"colonne bleue: c'est un copié collé spécial transposé des formules"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Les autres colonnes sont des recopies à dte"]
[]
["Time","Time ","Infused volume","Cp, calculated","DeltaTime","InfusionRate","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time","MINUTES",null,0,5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300]
["MIN","s","mls","µg/ml","DeltaTime,s","InfusionRate, amt/s","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time ","SECONDES",null,{"$f":"V105*60","v":0},300,{"$f":"X105*60","v":600},{"$f":"Y105*60","v":900},1200,1500,1800,2100,2400,2700,3000,3300,3600,3900,4200,4500,4800,5100,5400,5700,6000,6300,6600,6900,7200,7500,7800,8100,8400,8700,9000,9300,9600,9900,10200,10500,10800,11100,11400,11700,12000,12300,12600,12900,13200,13500,13800,14100,14400,14700,15000,15300,15600,15900,16200,16500,16800,17100,17400,17700,18000]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Infused volume","mls",null,0,{"$f":"KPTIVA!K32","v":0},{"$f":"KPTIVA!L32","v":0},{"$f":"KPTIVA!M32","v":0},{"$f":"KPTIVA!N32","v":0},{"$f":"KPTIVA!O32","v":0},{"$f":"KPTIVA!P32","v":0},{"$f":"KPTIVA!Q32","v":0},{"$f":"KPTIVA!R32","v":0},{"$f":"KPTIVA!S32","v":0},{"$f":"KPTIVA!T32","v":0},{"$f":"KPTIVA!U32","v":0},{"$f":"KPTIVA!V32","v":0},{"$f":"KPTIVA!W32","v":0},{"$f":"KPTIVA!X32","v":0},{"$f":"KPTIVA!Y32","v":0},{"$f":"KPTIVA!Z32","v":0},{"$f":"KPTIVA!AA32","v":0},{"$f":"KPTIVA!AB32","v":0},{"$f":"KPTIVA!AC32","v":0},{"$f":"KPTIVA!AD32","v":0},{"$f":"KPTIVA!AE32","v":0},{"$f":"KPTIVA!AF32","v":0},{"$f":"KPTIVA!AG32","v":0},{"$f":"KPTIVA!AH32","v":0},{"$f":"KPTIVA!AI32","v":0},{"$f":"KPTIVA!AJ32","v":0},{"$f":"KPTIVA!AK32","v":0},{"$f":"KPTIVA!AL32","v":0},{"$f":"KPTIVA!AM32","v":0},{"$f":"KPTIVA!AN32","v":0},{"$f":"KPTIVA!AO32","v":0},{"$f":"KPTIVA!AP32","v":0},{"$f":"KPTIVA!AQ32","v":0},{"$f":"KPTIVA!AR32","v":0},{"$f":"KPTIVA!AS32","v":0},{"$f":"KPTIVA!AT32","v":0},{"$f":"KPTIVA!AU32","v":0},{"$f":"KPTIVA!AV32","v":0},{"$f":"KPTIVA!AW32","v":0},{"$f":"KPTIVA!AX32","v":0},{"$f":"KPTIVA!AY32","v":0},{"$f":"KPTIVA!AZ32","v":0},{"$f":"KPTIVA!BA32","v":0},{"$f":"KPTIVA!BB32","v":0},{"$f":"KPTIVA!BC32","v":0},{"$f":"KPTIVA!BD32","v":0},{"$f":"KPTIVA!BE32","v":0},{"$f":"KPTIVA!BF32","v":0},{"$f":"KPTIVA!BG32","v":0},{"$f":"KPTIVA!BH32","v":0},{"$f":"KPTIVA!BI32","v":0},{"$f":"KPTIVA!BJ32","v":0},{"$f":"KPTIVA!BK32","v":0},{"$f":"KPTIVA!BL32","v":0},{"$f":"KPTIVA!BM32","v":0},{"$f":"KPTIVA!BN32","v":0},{"$f":"KPTIVA!BO32","v":0},{"$f":"KPTIVA!BP32","v":0},{"$f":"KPTIVA!BQ32","v":0},{"$f":"KPTIVA!BR32","v":0}]
[0,{"$f":"A108*60","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,"Cp, calculated","µg/ml",null,0,{"$f":"D109","v":0},{"$f":"X115+X116+X117","v":0},{"$f":"Y115+Y116+Y117","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[5,{"$f":"A109*60","v":300},{"$f":"KPTIVA!K32","v":0},{"$f":"K109+L109+M109","v":0},{"$f":"B109-B108","v":300},{"$f":"(C109-C108)/E109*$C$81","v":0},{"$f":"EXP(-K_Lambda1*$E109)","v":1.8042663400517567E-4},{"$f":"EXP(-K_Lambda2*$E109)","v":0.46879947565089014},{"$f":"EXP(-K_Lambda3*$E109)","v":0.97021894334647674},{"$f":"EXP(-K_Lambda4*$E109)","v":1},{"$f":"K108*G109+(1-G109)*$F109*K_PCoef1","v":0},{"$f":"L108*H109+(1-H109)*$F109*K_PCoef2","v":0},{"$f":"M108*I109+(1-I109)*$F109*K_PCoef3","v":0},{"$f":"N108*G109+(1-G109)*$F109*K_ECoef1","v":0},{"$f":"O108*H109+(1-H109)*$F109*K_ECoef2","v":0},{"$f":"P108*I109+(1-I109)*$F109*K_ECoef3","v":0},{"$f":"Q108*J109+(1-J109)*$F109*K_ECoef4","v":0},null,"DeltaTime","DeltaTime,s",null,0,{"$f":"E109","v":300},{"$f":"X106-W106","v":300},{"$f":"Y106-X106","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
[10,600,5,{"$f":"K110+L110+M110","v":1.7754699804516265},{"$f":"B110-B109","v":300},{"$f":"(C110-C109)/E110*$C$81","v":0.16666666666666666},{"$f":"EXP(-K_Lambda1*$E110)","v":1.8042663400517567E-4},{"$f":"EXP(-K_Lambda2*$E110)","v":0.46879947565089014},{"$f":"EXP(-K_Lambda3*$E110)","v":0.97021894334647674},{"$f":"EXP(-K_Lambda4*$E110)","v":1},{"$f":"K109*G110+(1-G110)*$F110*K_PCoef1","v":1.2290335103177947},{"$f":"L109*H110+(1-H110)*$F110*K_PCoef2","v":0.4543370245041935},{"$f":"M109*I110+(1-I110)*$F110*K_PCoef3","v":9.2099445629638135E-2},{"$f":"N109*G110+(1-G110)*$F110*K_ECoef1","v":0},{"$f":"O109*H110+(1-H110)*$F110*K_ECoef2","v":0},{"$f":"P109*I110+(1-I110)*$F110*K_ECoef3","v":0},{"$f":"Q109*J110+(1-J110)*$F110*K_ECoef4","v":0},null,"InfusionRate","InfusionRate, amt/s",null,0,{"$f":"F109","v":0},{"$f":"(X107-W107)/X109*$C$81","v":0},{"$f":"(Y107-X107)/Y109*$C$81","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
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[null,null,null,"la colonne Ce a été retirée",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I4","I4",null,0,{"$f":"J109","v":1},{"$f":"EXP(-K_Lambda4*X$109)","v":1},1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,{"$f":"EXP(-K_Lambda4*BD$109)","v":1},1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState2","eState2",null,0,{"$f":"O109","v":0},{"$f":"W119*X112+(1-X112)*X$110*K_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC119*BD112+(1-BD112)*BD$110*K_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState3","eState3",null,0,{"$f":"P109","v":0},{"$f":"W120*X113+(1-X113)*X$110*K_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC120*BD113+(1-BD113)*BD$110*K_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState4","eState4",null,0,{"$f":"Q109","v":0},{"$f":"W121*X114+(1-X114)*X$110*K_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC121*BD114+(1-BD114)*BD$110*K_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"Propofol","index":7,"n_rows":127,"n_cols":82,"rows_kept":127,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[18,0,18,14],[19,4,19,7],[20,4,20,7],[20,11,20,12],[21,4,21,7],[21,11,21,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[73,0,73,1],[27,4,27,7],[27,11,27,12],[34,0,34,1],[34,2,36,14],[37,2,39,14],[40,2,42,14],[43,2,45,14],[46,2,48,14],[49,2,51,14],[52,2,54,14],[57,0,57,1],[95,0,95,1],[96,0,96,1],[86,0,86,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[93,0,93,1],[94,0,94,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 001",null,null,null,null,"Revision",null,1.01]
[]
["Rugloop II© Propofol calculations validation"]
["Drug model:  Propofol Schnider"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Schnider et al.: Anesthesiology 1998, 88, 1170-1182\nAdjustment tpeak = 1.6min: Schnider et al.: “The influence of age on propofol pharmacodynamics”, Anesthesiology, 1999, 90,1502-1516\n"]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2002-02-01"]
[null,null,null,1.01,"Update with references",null,null,null,"TDS",null,null,"2002-02-07"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… REMEMBER: press the CalculateK41 button after entering your patient's data to match the k41 with the specified patient data. "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for remifentanil. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp & Ce values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
["Model:",null,"Unit of concentration : µg/ml"]
[]
[null,null,"Vc = 4.27"]
[null,null,"V2 = 18.9 – 0.391 * (age – 53)",null,null,null,null,null,null,null,null,"k10 = Cl 1/ Vc"]
[null,null,"V3 = 238",null,null,null,null,null,null,null,null,"k12 =  Cl 2/Vc"]
[null,null,"Cl 1 = 1.89 + 0.0456 * (mass – 77) – 0.0681 * (lbm – 59) + 0.0264 * (height – 177)",null,null,null,null,null,null,null,null,"k13 = Cl 3/Vc"]
[null,null,"Cl 2 = 1.29 – 0.024 * (age – 53)",null,null,null,null,null,null,null,null,"k21 = Cl 2/ V2"]
[null,null,"Cl 3 = 0.836",null,null,null,null,null,null,null,null,"k31 = Cl 3/V3"]
[]
[]
["Patient data",null,null,null,null,"Les entrées viennent de KPTIVA"]
[]
["Enter patient age",null,null,null,null,{"$f":"KPTIVA!E14","v":40},"years"]
["Enter patient weight ",null,null,null,null,{"$f":"Poids","v":70},"kg"]
["Enter patient height ",null,null,null,null,{"$f":"KPTIVA!E18","v":170},"cm"]
["Enter patient gender ",null,null,null,null,{"$f":"KPTIVA!E22","v":1},"(1 = MALE, 2 = FEMALE)"]
["Enter drug conc",null,null,null,null,{"$f":"KPTIVA!C35","v":10},"mg/ml"]
[]
["Schnider model covariates",null,null,null,null,null,"------>",null,null,"Schnider model K-values"]
[null,null,null,null,"Male","Female",null,null,null,null,0.5]
["Lbm",null,{"$f":"IF((F73=1),E78,IF((F73=2),F78,1/0))","v":55.297577854671282},null,{"$f":"1.1*F71-128*F71/F72*F71/F72","v":55.297577854671282},{"$f":"1.07*F71-148*F71/F72*F71/F72","v":49.806574394463674},null,null,null,"Vc",4.2699999999999996]
["BSA",null,{"$f":"POWER(F71,0.425)*POWER(F72,0.725)*0.007184","v":1.8097078017532484},null,null,null,null,null,null,"K10",{"$f":"$C$82/P_Vc","v":0.3836381611468116},"1/min"]
["v2",null,{"$f":"18.9-0.391*(F70-53)","v":23.982999999999997},null,null,null,null,null,null,"K12",{"$f":"$C$83/P_Vc","v":0.37517564402810311},"1/min"]
["v3",null,238,null,null,null,null,null,null,"K13",{"$f":"$C$84/P_Vc","v":0.19578454332552694},"1/min"]
["cl1",null,{"$f":"1.89+0.0456*(F71-77)-0.0681*(C78-59)+0.0264*(F72-177)","v":1.6381349480968854},null,null,null,null,null,null,"K21",{"$f":"$C$83/$C$80","v":6.6797314764624957E-2},"1/min"]
["cl2",null,{"$f":"1.29-0.024*(F70-53)","v":1.6020000000000001},null,null,null,null,null,null,"K31",{"$f":"$C$84/$C$81","v":3.5126050420168065E-3},"1/min"]
["cl3",null,0.83599999999999997,null,null,null,null,null,null,"K41",0.33877944946289063,"1/min"]
["Vc",null,4.2699999999999996]
["Tpeak",null,1.6,"min"]
["Drug conc[mg/ml]",null,{"$f":"F74","v":10}]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation",null,null,null,null,"K41 determinations - estimate for tpeak. "]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"K78","v":4.2699999999999996},"a0",{"$f":"P_K10*P_K21*P_K31","v":4.1673154312338204E-10},{"$f":"P_K10*P_K21","v":7.1183330571793017E-6},"_","PCoef1",{"$f":"(P_K21-P_Lambda1)*(P_K31-P_Lambda1)/(P_Lambda1-P_Lambda2)/(P_Lambda1-P_Lambda3)/P_Vc/P_Lambda1","v":13.874936164119326},{"$f":"(P_K21-P_Lambda1)/(P_Lambda2-P_Lambda1)/P_Vc/P_Lambda1","v":13.892221124264761},{"$f":"1/P_Vc/P_Lambda1","v":14.299423173364103},"ECoef1",{"$f":"P_PCoef1/(P_K41-P_Lambda1)*P_K41","v":-7.3002937531047527},{"$f":"J91/(P_K41-P_Lambda1)*P_K41","v":-7.3093882300147586},{"$f":"K91/(P_K41-P_Lambda1)*P_K41","v":-7.5236374734079483},null,"Table calculating dirac-impulse concentration result at time tpeak for a certain set of Kvalues"]
["K10",null,{"$f":"K79/60","v":6.3939693524468601E-3},"a1",{"$f":"P_K10*P_K31+P_K21*P_K31+P_K21*P_K13+P_K10*P_K21+P_K31*P_K12","v":1.1556646265292731E-5},{"$f":"(P_K10+P_K12+P_K21)","v":1.3760185332325661E-2},"_","PCoef2",{"$f":"(P_K21-P_Lambda2)*(P_K31-P_Lambda2)/(P_Lambda2-P_Lambda1)/(P_Lambda2-P_Lambda3)/P_Vc/P_Lambda2","v":9.6912020058075647},{"$f":"(P_K21-P_Lambda2)/(P_Lambda1-P_Lambda2)/P_Vc/P_Lambda2","v":10.015612488842773},0,"ECoef2",{"$f":"P_PCoef2/(P_K41-P_Lambda2)*P_K41","v":10.986871675489144},{"$f":"J92/(P_K41-P_Lambda2)*P_K41","v":11.354654365928925},0,null,"When the results Ceff have a peak it is what we want. "]
["K12",null,6.2529274004683852E-3,"a2",{"$f":"P_K10+P_K12+P_K13+P_K31+P_K21","v":1.7081804471784725E-2},"_","_","PCoef3",{"$f":"(P_K21-P_Lambda3)*(P_K31-P_Lambda3)/(P_Lambda3-P_Lambda2)/(P_Lambda3-P_Lambda1)/P_Vc/P_Lambda3","v":13.06088091034233},0,0,"ECoef3",{"$f":"P_PCoef3/(P_K41-P_Lambda3)*P_K41","v":13.149877346234735},0,0,null,"If the values keep increasing, k41 must increase."]
["K13",null,3.2630757220921155E-3,"p",{"$f":"P_a1-(P_a2*P_a2/3)","v":-8.5706035072135472E-5},"_","_",null,null,null,null,"ECoef4",{"$f":"(P_K41-P_K21)*(P_K41-P_K31)/(P_Lambda1-P_K41)/(P_Lambda2-P_K41)/(P_Lambda3-P_K41)/P_Vc","v":19.790563811650099},{"$f":"(P_K21-P_K41)/(P_Lambda1-P_K41)/(P_Lambda2-P_K41)/P_Vc","v":19.86256747719337},{"$f":"1/(P_Lambda1-P_K41)/P_Vc","v":21.823060646772053},null,"If the values keep decreasing, k41 must decrease."]
["K21",null,1.113288579410416E-3,"q",{"$f":"(2*P_a2*P_a2*P_a2/27)-(P_a1*P_a2/3)+P_a0","v":3.0381885314923148E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"E1'","E2'","E3'","E4'"]
["K31",null,5.8543417366946774E-5,"r1",{"$f":"SQRT(-(P_p*P_p*P_p)/27)","v":1.5269865942621246E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"P_ECoef1*P_Lambda1","v":-0.11956221222678842},{"$f":"P_ECoef2*P_Lambda2","v":7.3157709563415199E-3},{"$f":"P_ECoef3*P_Lambda3","v":5.0250272592979863E-4},{"$f":"P_ECoef4*P_Lambda4","v":0.11174393854451711}]
["K41",null,5.6463241577148441E-3,null,{"$f":"(MIN(MAX(-P_q/2/P_r1,-1),1))","v":-0.99483143562253673},null,null,null,null,"Modelling results ",null,null,null,null,null,null,null,null,"Ceff","I1'","I2'","I3'","I4'"]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-P_q/2)/P_r1,-1),1)))/3","v":1.0132923799514806},"_","_",null,null,"Lambda1",{"$f":"IF(P_K31>0,E103,IF(P_K21>0,F103,G103))","v":1.6377726194365758E-2},null,null,null,null,null,"T1",{"$f":"C86*60*0.99","v":95.039999999999992},{"$f":"T98*$T$96+U98*$U$96+V98*$V$96+W98*$W$96","v":4.7495014023368032E-2},{"$f":"EXP(-P_Lambda1*$R$98)","v":0.21086459159413795},{"$f":"EXP(-P_Lambda2*$R$98)","v":0.93867704942558261},{"$f":"EXP(-P_Lambda3*$R$98)","v":0.99637477681582765},{"$f":"EXP(-P_Lambda4*$R$98)","v":0.5847173868107558}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(P_r1)/3)","v":1.0689935146179046E-2},"_","_",null,null,"Lambda2",{"$f":"IF(P_K31>0,E104,IF(P_K21>0,F104,G104))","v":6.6586478593924376E-4},null,null,null,null,null,"T2",{"$f":"C86*60","v":96},{"$f":"T99*$T$96+U99*$U$96+V99*$V$96+W99*$W$96","v":4.7530689283178121E-2},{"$f":"EXP(-P_Lambda1*$R$99)","v":0.20757517522968502},{"$f":"EXP(-P_Lambda2*$R$99)","v":0.93807721045072157},{"$f":"EXP(-P_Lambda3*$R$99)","v":0.99633822552559026},{"$f":"EXP(-P_Lambda4*$R$99)","v":0.58155651750020765}]
["L1",{"$f":"(POWER(-E100,3)+POWER(E100,2)*P_a2-E100*P_a1+P_a0)<0.000000000000001","v":true},{"$f":"POWER(F100,2)-P__a1*F100+P__a0","v":0},"L1",{"$f":"-(COS(P_Phi)*P_r1_Use-P_a2/3)","v":3.8213491479727191E-5},{"$f":"-(-P__a1+SQRT(P__a1*P__a1-4*P__a0))/2","v":5.3837822621772505E-4},{"$f":"P_K10","v":6.3939693524468601E-3},null,null,"Lambda3",{"$f":"IF(P_K31>0,E105,IF(P_K21>0,F105,G105))","v":3.8213491479727191E-5},null,null,null,null,null,"T3",{"$f":"C86*60*1.01","v":96.960000000000008},{"$f":"T100*$T$96+U100*$U$96+V100*$V$96+W100*$W$96","v":4.7562141532590224E-2},{"$f":"EXP(-P_Lambda1*$R$100)","v":0.20433707264881681},{"$f":"EXP(-P_Lambda2*$R$100)","v":0.93747775478851958},{"$f":"EXP(-P_Lambda3*$R$100)","v":0.99630167557621052},{"$f":"EXP(-P_Lambda4*$R$100)","v":0.57841273523893111}]
["L2",{"$f":"(POWER(-E101,3)+POWER(E101,2)*P_a2-E101*P_a1+P_a0)<0.000000000000001","v":true},{"$f":"POWER(F101,2)-F101*P__a1+P__a0","v":0},"L2",{"$f":"-(COS(P_Phi+PI()*2/3)*P_r1_Use-P_a2/3)","v":1.6377726194365758E-2},{"$f":"-(-P__a1-SQRT(P__a1*P__a1-4*P__a0))/2","v":1.3221807106107937E-2},0,null,null,"Lambda4",{"$f":"P_K41","v":5.6463241577148441E-3},null,null,null,null,null,null,null,null,null,null,null,null,"Colonne des zéros"]
["L3",{"$f":"(POWER(-E102,3)+POWER(E102,2)*P_a2-E102*P_a1+P_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(P_Phi+PI()*4/3)*P_r1_Use-P_a2/3)","v":6.6586478593924376E-4},0,0,null,null,"PCoef1",{"$f":"IF(P_K31>0,I91,IF(P_K21>0,J91,K91))","v":13.874936164119326}]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E100,E101),E102)","v":1.6377726194365758E-2},{"$f":"MAX(MAX(F100,F101),F102)","v":1.3221807106107937E-2},{"$f":"MAX(MAX(G100,G101),G102)","v":6.3939693524468601E-3},null,null,"PCoef2",{"$f":"IF(P_K31>0,I92,IF(P_K21>0,J92,K92))","v":9.6912020058075647},null,null,null,null,null,null,null,null,null,null,null,null,"Colonne liée à la première ligne de formules"]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E103<>E100,E105<>E100),E100,IF(AND(E103<>E101,E105<>E101),E101,E102))","v":6.6586478593924376E-4},{"$f":"IF(AND(F103<>F100,F105<>F100),F100,IF(AND(F103<>F101,F105<>F101),F101,F102))","v":5.3837822621772505E-4},{"$f":"IF(AND(G103<>G100,G105<>G100),G100,IF(AND(G103<>G101,G105<>G101),G101,G102))","v":0},null,null,"PCoef3",{"$f":"IF(P_K31>0,I93,IF(P_K21>0,J93,K93))","v":13.06088091034233}]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E100,E101),E102)","v":3.8213491479727191E-5},{"$f":"MIN(MIN(F100,F101),F102)","v":0},{"$f":"MIN(MIN(G100,G101),G102)","v":0},null,null,"ECoef1",{"$f":"IF(P_K31>0,M91,IF(P_K21>0,N91,O91))","v":-7.3002937531047527},null,"Ctrl F3","permet de renommer tous les noms d'une feuille",null,null,null,null,null,null,null,null,null,"Première colonne de formules copiée par transposition de l'horizontale bleue"]
[null,null,null,null,null,null,null,null,null,"ECoef2",{"$f":"IF(P_K31>0,M92,IF(P_K21>0,N92,O92))","v":10.986871675489144}]
[null,null,null,null,null,null,null,null,null,"ECoef3",{"$f":"IF(P_K31>0,M93,IF(P_K21>0,N93,O93))","v":13.149877346234735},null,null,null,null,null,null,null,null,null,null,null,null,"Les autres colonnes sont des recopies à dte"]
[null,null,null,null,null,null,null,null,null,"ECoef4",{"$f":"IF(P_K31>0,M94,IF(P_K21>0,N94,O94))","v":19.790563811650099}]
[]
["Time","Time ","Infused volume","Cp, calculated","Ce,calculated","DeltaTime","InfusionRate","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time","MINUTES",0,5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300]
["MINUTES","s","mls","µg/ml","µg/ml","DeltaTime,s","InfusionRate, amt/s","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time ","s",0,{"$f":"W110*60","v":300},{"$f":"X110*60","v":600},900,1200,1500,1800,2100,2400,2700,3000,3300,3600,3900,4200,4500,4800,5100,5400,5700,6000,6300,6600,6900,7200,7500,7800,8100,8400,8700,9000,9300,9600,9900,10200,10500,10800,11100,11400,11700,12000,12300,12600,12900,13200,13500,13800,14100,14400,14700,15000,15300,15600,15900,16200,16500,16800,17100,17400,17700,18000]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Infused volume","mls",0,{"$f":"KPTIVA!K37","v":0},{"$f":"KPTIVA!L37","v":0},{"$f":"KPTIVA!M37","v":0},{"$f":"KPTIVA!N37","v":0},{"$f":"KPTIVA!O37","v":0},{"$f":"KPTIVA!P37","v":0},{"$f":"KPTIVA!Q37","v":0},{"$f":"KPTIVA!R37","v":0},{"$f":"KPTIVA!S37","v":0},{"$f":"KPTIVA!T37","v":0},{"$f":"KPTIVA!U37","v":0},{"$f":"KPTIVA!V37","v":0},{"$f":"KPTIVA!W37","v":0},{"$f":"KPTIVA!X37","v":0},{"$f":"KPTIVA!Y37","v":0},{"$f":"KPTIVA!Z37","v":0},{"$f":"KPTIVA!AA37","v":0},{"$f":"KPTIVA!AB37","v":0},{"$f":"KPTIVA!AC37","v":0},{"$f":"KPTIVA!AD37","v":0},{"$f":"KPTIVA!AE37","v":0},{"$f":"KPTIVA!AF37","v":0},{"$f":"KPTIVA!AG37","v":0},{"$f":"KPTIVA!AH37","v":0},{"$f":"KPTIVA!AI37","v":0},{"$f":"KPTIVA!AJ37","v":0},{"$f":"KPTIVA!AK37","v":0},{"$f":"KPTIVA!AL37","v":0},{"$f":"KPTIVA!AM37","v":0},{"$f":"KPTIVA!AN37","v":0},{"$f":"KPTIVA!AO37","v":0},{"$f":"KPTIVA!AP37","v":0},{"$f":"KPTIVA!AQ37","v":0},{"$f":"KPTIVA!AR37","v":0},{"$f":"KPTIVA!AS37","v":0},{"$f":"KPTIVA!AT37","v":0},{"$f":"KPTIVA!AU37","v":0},{"$f":"KPTIVA!AV37","v":0},{"$f":"KPTIVA!AW37","v":0},{"$f":"KPTIVA!AX37","v":0},{"$f":"KPTIVA!AY37","v":0},{"$f":"KPTIVA!AZ37","v":0},{"$f":"KPTIVA!BA37","v":0},{"$f":"KPTIVA!BB37","v":0},{"$f":"KPTIVA!BC37","v":0},{"$f":"KPTIVA!BD37","v":0},{"$f":"KPTIVA!BE37","v":0},{"$f":"KPTIVA!BF37","v":0},{"$f":"KPTIVA!BG37","v":0},{"$f":"KPTIVA!BH37","v":0},{"$f":"KPTIVA!BI37","v":0},{"$f":"KPTIVA!BJ37","v":0},{"$f":"KPTIVA!BK37","v":0},{"$f":"KPTIVA!BL37","v":0},{"$f":"KPTIVA!BM37","v":0},{"$f":"KPTIVA!BN37","v":0},{"$f":"KPTIVA!BO37","v":0},{"$f":"KPTIVA!BP37","v":0},{"$f":"KPTIVA!BQ37","v":0},{"$f":"KPTIVA!BR37","v":0}]
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[5,{"$f":"A114*60","v":300},{"$f":"KPTIVA!K37","v":0},{"$f":"L114+M114+N114","v":0},{"$f":"O114+P114+Q114+R114","v":0},{"$f":"B114-B113","v":300},{"$f":"(C114-C113)/F114*$C$87","v":0},{"$f":"EXP(-P_Lambda1*$F114)","v":7.3480679937064928E-3},{"$f":"EXP(-P_Lambda2*$F114)","v":0.81892773409387642},{"$f":"EXP(-P_Lambda3*$F114)","v":0.98860141435678661},{"$f":"EXP(-P_Lambda4*$F114)","v":0.18380180524579801},{"$f":"L113*H114+(1-H114)*$G114*P_PCoef1","v":0},{"$f":"M113*I114+(1-I114)*$G114*P_PCoef2","v":0},{"$f":"N113*J114+(1-J114)*$G114*P_PCoef3","v":0},{"$f":"O113*H114+(1-H114)*$G114*P_ECoef1","v":0},{"$f":"P113*I114+(1-I114)*$G114*P_ECoef2","v":0},{"$f":"Q113*J114+(1-J114)*$G114*P_ECoef3","v":0},{"$f":"R113*K114+(1-K114)*$G114*P_ECoef4","v":0},null,"Ce,calculated","µg/ml",0,{"$f":"E114","v":0},{"$f":"X124+X125+X126+X127","v":0},{"$f":"Y124+Y125+Y126+Y127","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[10,{"$f":"A115*60","v":600},20,{"$f":"L115+M115+N115","v":10.451110443969956},7.3637863404221147,{"$f":"B115-B114","v":300},{"$f":"(C115-C114)/F115*$C$87","v":0.66666666666666663},7.3480679937064928E-3,0.81892773409387642,0.98860141435678661,0.18380180524579801,{"$f":"L114*H115+(1-H115)*$G115*P_PCoef1","v":9.1819881265180268},1.1698719376970304,9.9250379754898602E-2,-4.8311004654886061,1.3262784996670851,9.9926668752538819E-2,10.768681637491097,null,"DeltaTime","DeltaTime,s",0,{"$f":"F114","v":300},{"$f":"X111-W111","v":300},{"$f":"Y111-X111","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"InfusionRate","InfusionRate, amt/s",0,{"$f":"G114","v":0},{"$f":"(X112-W112)/X115*$C$87","v":0},{"$f":"(Y112-X112)/Y115*$C$87","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
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[null,"4 colonnes ont été retirées (comparaisons)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I2","I2",0,{"$f":"I114","v":0.81892773409387642},{"$f":"EXP(-P_Lambda2*X$115)","v":0.81892773409387642},0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,{"$f":"EXP(-P_Lambda2*BD$115)","v":0.81892773409387642},0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642,0.81892773409387642]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState1","PState1",0,{"$f":"L114","v":0},{"$f":"W121*X117+(1-X117)*X$116*P_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC121*BD117+(1-BD117)*BD$116*P_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState2","PState2",0,{"$f":"M114","v":0},{"$f":"W122*X118+(1-X118)*X$116*P_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC122*BD118+(1-BD118)*BD$116*P_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState3","PState3",0,{"$f":"N114","v":0},{"$f":"W123*X119+(1-X119)*X$116*P_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC123*BD119+(1-BD119)*BD$116*P_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState1","eState1",0,{"$f":"O114","v":0},{"$f":"W124*X117+(1-X117)*X$116*P_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC124*BD117+(1-BD117)*BD$116*P_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState2","eState2",0,{"$f":"P114","v":0},{"$f":"W125*X118+(1-X118)*X$116*P_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC125*BD118+(1-BD118)*BD$116*P_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState3","eState3",0,{"$f":"Q114","v":0},{"$f":"W126*X119+(1-X119)*X$116*P_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC126*BD119+(1-BD119)*BD$116*P_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState4","eState4",0,{"$f":"R114","v":0},{"$f":"W127*X120+(1-X120)*X$116*P_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC127*BD120+(1-BD120)*BD$116*P_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"Sufenta","index":8,"n_rows":127,"n_cols":82,"rows_kept":127,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[18,0,18,14],[19,4,19,7],[20,4,20,7],[20,11,20,12],[21,4,21,7],[21,11,21,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[73,0,73,1],[27,4,27,7],[27,11,27,12],[34,0,34,1],[34,2,36,14],[37,2,39,14],[40,2,42,14],[43,2,45,14],[46,2,48,14],[49,2,51,14],[52,2,54,14],[57,0,57,1],[95,0,95,1],[96,0,96,1],[86,0,86,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[93,0,93,1],[94,0,94,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 010",null,null,null,null,"Revision",null,1]
[]
["Rugloop II© calculations validation"]
["Drug model:  Sufentanil Gepts, not weight adjusted"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Gepts et al.: Anesthesiology 1995, 83, 1194-1204                                                                                             Adjustment tpeak = 5.588 min: from Shafer / Varvel "]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2003-01-10"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… AFTER filling in these values, press \"Calculate K41\" button to update the K41 value to your specifications. "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for remifentanil. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp & Ce values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
["Model:",null,"Unit of concentration : ng/ml"]
[]
[null,null,"Vc = 14.3"]
[null,null,"k10 = 0.0645"]
[null,null,"k12 = 0.1086"]
[null,null,"k13 = 0.0229"]
[null,null,"k21 = 0.0245"]
[null,null,"k31 = 0.0013"]
[]
[]
["Patient data"]
[]
["Enter patient age",null,null,null,null,{"$f":"KPTIVA!E14","v":40},"years"]
["Enter patient weight ",null,null,null,null,{"$f":"Poids","v":70},"kg"]
["Enter patient height ",null,null,null,null,{"$f":"KPTIVA!E18","v":170},"cm"]
["Enter patient gender ",null,null,null,null,{"$f":"KPTIVA!E22","v":1},"(1 = MALE, 2 = FEMALE)"]
["Enter drug conc",null,null,null,null,{"$f":"Concentration_Sufenta","v":5},"µg/ml"]
[]
["Model covariates",null,null,null,null,null,"------>",null,null,"Model K-values"]
[null,null,null,null,"Male","Female",null,null,null,null,0.5]
["Lbm",null,{"$f":"IF((F73=1),E78,IF((F73=2),F78,1/0))","v":55.297577854671282},null,{"$f":"1.1*F71-128*F71/F72*F71/F72","v":55.297577854671282},{"$f":"1.07*F71-148*F71/F72*F71/F72","v":49.806574394463674},null,null,null,"Vc",14.3]
["BSA",null,{"$f":"POWER(F71,0.425)*POWER(F72,0.725)*0.007184","v":1.8097078017532484},null,null,null,null,null,null,"K10",6.4500000000000002E-2,"1/min"]
[null,null,null,null,null,null,null,null,null,"K12",0.1086,"1/min"]
[null,null,null,null,null,null,null,null,null,"K13",2.29E-2,"1/min"]
[null,null,null,null,null,null,null,null,null,"K21",2.4500000000000001E-2,"1/min"]
[null,null,null,null,null,null,null,null,null,"K31",1.2999999999999999E-3,"1/min"]
[null,null,null,null,null,null,null,null,null,"K41",0.17630958557128906,"1/min"]
[]
["Tpeak",null,5.5880000000000001,"min"]
["Drug conc[µg/ml]",null,{"$f":"F74","v":5}]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation",null,null,null,null,"K41 determinations - estimate for tpeak. "]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"K78","v":14.3},"a0",{"$f":"S_K10*S_K21*S_K31","v":9.5107638888888895E-12},{"$f":"S_K10*S_K21","v":4.3895833333333335E-7},"_","PCoef1",{"$f":"(S_K21-S_Lambda1)*(S_K31-S_Lambda1)/(S_Lambda1-S_Lambda2)/(S_Lambda1-S_Lambda3)/S_Vc/S_Lambda1","v":18.50099597516261},{"$f":"(S_K21-S_Lambda1)/(S_Lambda2-S_Lambda1)/S_Vc/S_Lambda1","v":18.533055237784541},{"$f":"1/S_Vc/S_Lambda1","v":19.937207252239403},"ECoef1",{"$f":"S_PCoef1/(S_K41-S_Lambda1)*S_K41","v":-95.541084524902061},{"$f":"J91/(S_K41-S_Lambda1)*S_K41","v":-95.706641921059543},{"$f":"K91/(S_K41-S_Lambda1)*S_K41","v":-102.95783026134912},null,"Table calculating dirac-impulse concentration result at time tpeak for a certain set of Kvalues"]
["K10",null,{"$f":"K79/60","v":1.075E-3},"a1",{"$f":"S_K10*S_K31+S_K21*S_K31+S_K21*S_K13+S_K10*S_K21+S_K31*S_K12","v":6.6616111111111117E-7},{"$f":"(S_K10+S_K12+S_K21)","v":3.2933333333333334E-3},"_","PCoef2",{"$f":"(S_K21-S_Lambda2)*(S_K31-S_Lambda2)/(S_Lambda2-S_Lambda1)/(S_Lambda2-S_Lambda3)/S_Vc/S_Lambda2","v":27.296855331738715},{"$f":"(S_K21-S_Lambda2)/(S_Lambda1-S_Lambda2)/S_Vc/S_Lambda2","v":28.382636139575013},0,"ECoef2",{"$f":"S_PCoef2/(S_K41-S_Lambda2)*S_K41","v":29.009958297836054},{"$f":"J92/(S_K41-S_Lambda2)*S_K41","v":30.163880812833515},0,null,"When the results Ceff have a peak it is what we want. "]
["K12",null,1.81E-3,"a2",{"$f":"S_K10+S_K12+S_K13+S_K31+S_K21","v":3.6966666666666671E-3},"_","_","PCoef3",{"$f":"(S_K21-S_Lambda3)*(S_K31-S_Lambda3)/(S_Lambda3-S_Lambda2)/(S_Lambda3-S_Lambda1)/S_Vc/S_Lambda3","v":19.253376535035081},0,0,"ECoef3",{"$f":"S_PCoef3/(S_K41-S_Lambda3)*S_K41","v":19.356309053257778},0,0,null,"If the values keep increasing, k41 must increase."]
["K13",null,3.8166666666666666E-4,"p",{"$f":"S_a1-(S_a2*S_a2/3)","v":-3.8889537037037055E-6},"_","_",null,null,null,null,"ECoef4",{"$f":"(S_K41-S_K21)*(S_K41-S_K31)/(S_Lambda1-S_K41)/(S_Lambda2-S_K41)/(S_Lambda3-S_K41)/S_Vc","v":112.22604501574463},{"$f":"(S_K21-S_K41)/(S_Lambda1-S_K41)/(S_Lambda2-S_K41)/S_Vc","v":112.4584524855856},{"$f":"1/(S_Lambda1-S_K41)/S_Vc","v":122.89503751358852},null,"If the values keep decreasing, k41 must decrease."]
["K21",null,4.0833333333333336E-4,"q",{"$f":"(2*S_a2*S_a2*S_a2/27)-(S_a1*S_a2/3)+S_a0","v":2.9305947055898502E-9},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"E1'","E2'","E3'","E4'"]
["K31",null,2.1666666666666667E-5,"r1",{"$f":"SQRT(-(S_p*S_p*S_p)/27)","v":1.4759351560817488E-9},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"S_ECoef1*S_Lambda1","v":-0.33511186584423314},{"$f":"S_ECoef2*S_Lambda2","v":5.0339412332261269E-3},{"$f":"S_ECoef3*S_Lambda3","v":3.0246649382755154E-4},{"$f":"S_ECoef4*S_Lambda4","v":0.3297754581171794}]
["K41",null,2.9384930928548175E-3,null,{"$f":"(MIN(MAX(-S_q/2/S_r1,-1),1))","v":-0.99279249956003179},null,null,null,null,"Modelling results ",null,null,null,null,null,null,null,null,"Ceff","I1'","I2'","I3'","I4'"]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-S_q/2)/S_r1,-1),1)))/3","v":1.0071526454871655},"_","_",null,null,"Lambda1",{"$f":"IF(S_K31>0,E103,IF(S_K21>0,F103,G103))","v":3.5075158243246521E-3},null,null,null,null,null,"T1",{"$f":"C86*60*0.99","v":331.92720000000003},{"$f":"T98*$T$96+U98*$U$96+V98*$V$96+W98*$W$96","v":2.4787915073743338E-2},{"$f":"EXP(-S_Lambda1*$R$98)","v":0.31215984254140444},{"$f":"EXP(-S_Lambda2*$R$98)","v":0.94402981222306814},{"$f":"EXP(-S_Lambda3*$R$98)","v":0.99482665121530689},{"$f":"EXP(-S_Lambda4*$R$98)","v":0.37705440766592363}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(S_r1)/3)","v":2.277119145968932E-3},"_","_",null,null,"Lambda2",{"$f":"IF(S_K31>0,E104,IF(S_K21>0,F104,G104))","v":1.7352459391855191E-4},null,null,null,null,null,"T2",{"$f":"C86*60","v":335.28000000000003},{"$f":"T99*$T$96+U99*$U$96+V99*$V$96+W99*$W$96","v":2.4789088039075965E-2},{"$f":"EXP(-S_Lambda1*$R$99)","v":0.3085103441960429},{"$f":"EXP(-S_Lambda2*$R$99)","v":0.9434807417807316},{"$f":"EXP(-S_Lambda3*$R$99)","v":0.99477453193537679},{"$f":"EXP(-S_Lambda4*$R$99)","v":0.37335783943473566}]
["L1",{"$f":"(POWER(-E100,3)+POWER(E100,2)*S_a2-E100*S_a1+S_a0)<0.000000000000001","v":true},{"$f":"POWER(F100,2)-S__a1*F100+S__a0","v":0},"L1",{"$f":"-(COS(S_Phi)*S_r1_Use-S_a2/3)","v":1.5626248423464013E-5},{"$f":"-(-S__a1+SQRT(S__a1*S__a1-4*S__a0))/2","v":1.391678183162682E-4},{"$f":"S_K10","v":1.075E-3},null,null,"Lambda3",{"$f":"IF(S_K31>0,E105,IF(S_K21>0,F105,G105))","v":1.5626248423464013E-5},null,null,null,null,null,"T3",{"$f":"C86*60*1.01","v":338.63280000000003},{"$f":"T100*$T$96+U100*$U$96+V100*$V$96+W100*$W$96","v":2.4787915693868789E-2},{"$f":"EXP(-S_Lambda1*$R$100)","v":0.30490351257572945},{"$f":"EXP(-S_Lambda2*$R$100)","v":0.94293199069096922},{"$f":"EXP(-S_Lambda3*$R$100)","v":0.99472241538599193},{"$f":"EXP(-S_Lambda4*$R$100)","v":0.36969751164102826}]
["L2",{"$f":"(POWER(-E101,3)+POWER(E101,2)*S_a2-E101*S_a1+S_a0)<0.000000000000001","v":true},{"$f":"POWER(F101,2)-F101*S__a1+S__a0","v":0},"L2",{"$f":"-(COS(S_Phi+PI()*2/3)*S_r1_Use-S_a2/3)","v":3.5075158243246521E-3},{"$f":"-(-S__a1-SQRT(S__a1*S__a1-4*S__a0))/2","v":3.154165515017065E-3},0,null,null,"Lambda4",{"$f":"S_K41","v":2.9384930928548175E-3}]
["L3",{"$f":"(POWER(-E102,3)+POWER(E102,2)*S_a2-E102*S_a1+S_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(S_Phi+PI()*4/3)*S_r1_Use-S_a2/3)","v":1.7352459391855191E-4},0,0,null,null,"PCoef1",{"$f":"IF(S_K31>0,I91,IF(S_K21>0,J91,K91))","v":18.50099597516261}]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E100,E101),E102)","v":3.5075158243246521E-3},{"$f":"MAX(MAX(F100,F101),F102)","v":3.154165515017065E-3},{"$f":"MAX(MAX(G100,G101),G102)","v":1.075E-3},null,null,"PCoef2",{"$f":"IF(S_K31>0,I92,IF(S_K21>0,J92,K92))","v":27.296855331738715}]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E103<>E100,E105<>E100),E100,IF(AND(E103<>E101,E105<>E101),E101,E102))","v":1.7352459391855191E-4},{"$f":"IF(AND(F103<>F100,F105<>F100),F100,IF(AND(F103<>F101,F105<>F101),F101,F102))","v":1.391678183162682E-4},{"$f":"IF(AND(G103<>G100,G105<>G100),G100,IF(AND(G103<>G101,G105<>G101),G101,G102))","v":0},null,null,"PCoef3",{"$f":"IF(S_K31>0,I93,IF(S_K21>0,J93,K93))","v":19.253376535035081}]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E100,E101),E102)","v":1.5626248423464013E-5},{"$f":"MIN(MIN(F100,F101),F102)","v":0},{"$f":"MIN(MIN(G100,G101),G102)","v":0},null,null,"ECoef1",{"$f":"IF(S_K31>0,M91,IF(S_K21>0,N91,O91))","v":-95.541084524902061}]
[null,null,null,null,null,null,null,null,null,"ECoef2",{"$f":"IF(S_K31>0,M92,IF(S_K21>0,N92,O92))","v":29.009958297836054}]
[null,null,null,null,null,null,null,null,null,"ECoef3",{"$f":"IF(S_K31>0,M93,IF(S_K21>0,N93,O93))","v":19.356309053257778}]
[null,null,null,null,null,null,null,null,null,"ECoef4",{"$f":"IF(S_K31>0,M94,IF(S_K21>0,N94,O94))","v":112.22604501574463}]
[]
["Time","Time ","Infused volume","Cp, calculated","Ce,calculated","DeltaTime","InfusionRate","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time","MIN",0,5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300]
["MIN","s","mls","ng/ml","ng/ml","DeltaTime,s","InfusionRate, amt/s","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time ","s",0,{"$f":"W110*60","v":300},{"$f":"X110*60","v":600},{"$f":"Y110*60","v":900},1200,1500,1800,2100,2400,2700,3000,3300,3600,3900,4200,4500,4800,5100,5400,5700,6000,6300,6600,6900,7200,7500,7800,8100,8400,8700,9000,9300,9600,9900,10200,10500,10800,11100,11400,11700,12000,12300,12600,12900,13200,13500,13800,14100,14400,14700,15000,15300,15600,15900,16200,16500,16800,17100,17400,17700,18000]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Infused volume","mls",0,{"$f":"KPTIVA!K43","v":0},{"$f":"KPTIVA!L43","v":0},{"$f":"KPTIVA!M43","v":0},{"$f":"KPTIVA!N43","v":0},{"$f":"KPTIVA!O43","v":0},{"$f":"KPTIVA!P43","v":0},{"$f":"KPTIVA!Q43","v":0},{"$f":"KPTIVA!R43","v":0},{"$f":"KPTIVA!S43","v":0},{"$f":"KPTIVA!T43","v":0},{"$f":"KPTIVA!U43","v":0},{"$f":"KPTIVA!V43","v":0},{"$f":"KPTIVA!W43","v":0},{"$f":"KPTIVA!X43","v":0},{"$f":"KPTIVA!Y43","v":0},{"$f":"KPTIVA!Z43","v":0},{"$f":"KPTIVA!AA43","v":0},{"$f":"KPTIVA!AB43","v":0},{"$f":"KPTIVA!AC43","v":0},{"$f":"KPTIVA!AD43","v":0},{"$f":"KPTIVA!AE43","v":0},{"$f":"KPTIVA!AF43","v":0},{"$f":"KPTIVA!AG43","v":0},{"$f":"KPTIVA!AH43","v":0},{"$f":"KPTIVA!AI43","v":0},{"$f":"KPTIVA!AJ43","v":0},{"$f":"KPTIVA!AK43","v":0},{"$f":"KPTIVA!AL43","v":0},{"$f":"KPTIVA!AM43","v":0},{"$f":"KPTIVA!AN43","v":0},{"$f":"KPTIVA!AO43","v":0},{"$f":"KPTIVA!AP43","v":0},{"$f":"KPTIVA!AQ43","v":0},{"$f":"KPTIVA!AR43","v":0},{"$f":"KPTIVA!AS43","v":0},{"$f":"KPTIVA!AT43","v":0},{"$f":"KPTIVA!AU43","v":0},{"$f":"KPTIVA!AV43","v":0},{"$f":"KPTIVA!AW43","v":0},{"$f":"KPTIVA!AX43","v":0},{"$f":"KPTIVA!AY43","v":0},{"$f":"KPTIVA!AZ43","v":0},{"$f":"KPTIVA!BA43","v":0},{"$f":"KPTIVA!BB43","v":0},{"$f":"KPTIVA!BC43","v":0},{"$f":"KPTIVA!BD43","v":0},{"$f":"KPTIVA!BE43","v":0},{"$f":"KPTIVA!BF43","v":0},{"$f":"KPTIVA!BG43","v":0},{"$f":"KPTIVA!BH43","v":0},{"$f":"KPTIVA!BI43","v":0},{"$f":"KPTIVA!BJ43","v":0},{"$f":"KPTIVA!BK43","v":0},{"$f":"KPTIVA!BL43","v":0},{"$f":"KPTIVA!BM43","v":0},{"$f":"KPTIVA!BN43","v":0},{"$f":"KPTIVA!BO43","v":0},{"$f":"KPTIVA!BP43","v":0},{"$f":"KPTIVA!BQ43","v":0},{"$f":"KPTIVA!BR43","v":0}]
[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,"Cp, calculated","ng/ml",0,{"$f":"D114","v":0},{"$f":"X121+X122+X123","v":0},{"$f":"Y121+Y122+Y123","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[5,{"$f":"A114*60","v":300},{"$f":"KPTIVA!K43","v":0},{"$f":"L114+M114+N114","v":0},{"$f":"O114+P114+Q114+R114","v":0},{"$f":"B114-B113","v":300},{"$f":"IF(F114>0,(C114-C113)/F114*$C$87,#N/A)","v":0},{"$f":"EXP(-S_Lambda1*$F114)","v":0.34914961677062056},{"$f":"EXP(-S_Lambda2*$F114)","v":0.94927439764718491},{"$f":"EXP(-S_Lambda3*$F114)","v":0.99532309640660288},{"$f":"EXP(-S_Lambda4*$F114)","v":0.41414135432856303},{"$f":"L113*H114+(1-H114)*$G114*S_PCoef1","v":0},{"$f":"M113*I114+(1-I114)*$G114*S_PCoef2","v":0},{"$f":"N113*J114+(1-J114)*$G114*S_PCoef3","v":0},{"$f":"O113*H114+(1-H114)*$G114*S_ECoef1","v":0},{"$f":"P113*I114+(1-I114)*$G114*S_ECoef2","v":0},{"$f":"Q113*J114+(1-J114)*$G114*S_ECoef3","v":0},{"$f":"R113*K114+(1-K114)*$G114*S_ECoef4","v":0},null,"Ce,calculated","ng/ml",0,{"$f":"E114","v":0},{"$f":"X124+X125+X126+X127","v":0},{"$f":"Y124+Y125+Y126+Y127","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[10,600,null,0,0,{"$f":"B115-B114","v":300},{"$f":"IF(F115>0,(C115-C114)/F115*$C$87,#N/A)","v":0},0.34914961677062056,0.94927439764718491,0.99532309640660288,0.41414135432856303,0,0,0,0,0,0,0,null,"DeltaTime","DeltaTime,s",0,{"$f":"F114","v":300},{"$f":"X111-W111","v":300},{"$f":"Y111-X111","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I4","I4",0,{"$f":"K114","v":0.41414135432856303},{"$f":"EXP(-S_Lambda4*X$115)","v":0.41414135432856303},0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,{"$f":"EXP(-S_Lambda4*BD$115)","v":0.41414135432856303},0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303,0.41414135432856303]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState1","PState1",0,{"$f":"L114","v":0},{"$f":"W121*X117+(1-X117)*X$116*S_PCoef1","v":0},{"$f":"X121*Y117+(1-Y117)*Y$116*S_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC121*BD117+(1-BD117)*BD$116*S_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState2","PState2",0,{"$f":"M114","v":0},{"$f":"W122*X118+(1-X118)*X$116*S_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC122*BD118+(1-BD118)*BD$116*S_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState3","PState3",0,{"$f":"N114","v":0},{"$f":"W123*X119+(1-X119)*X$116*S_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC123*BD119+(1-BD119)*BD$116*S_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState1","eState1",0,{"$f":"O114","v":0},{"$f":"W124*X117+(1-X117)*X$116*S_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC124*BD117+(1-BD117)*BD$116*S_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState2","eState2",0,{"$f":"P114","v":0},{"$f":"W125*X118+(1-X118)*X$116*S_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC125*BD118+(1-BD118)*BD$116*S_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState3","eState3",0,{"$f":"Q114","v":0},{"$f":"W126*X119+(1-X119)*X$116*S_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC126*BD119+(1-BD119)*BD$116*S_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState4","eState4",0,{"$f":"R114","v":0},{"$f":"W127*X120+(1-X120)*X$116*S_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC127*BD120+(1-BD120)*BD$116*S_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"Rapifen","index":9,"n_rows":127,"n_cols":83,"rows_kept":127,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[18,0,18,14],[19,4,19,7],[20,4,20,7],[20,11,20,12],[21,4,21,7],[21,11,21,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[73,0,73,1],[27,4,27,7],[27,11,27,12],[34,0,34,1],[34,2,36,14],[37,2,39,14],[40,2,42,14],[43,2,45,14],[46,2,48,14],[49,2,51,14],[52,2,54,14],[57,0,57,1],[95,0,95,1],[96,0,96,1],[86,0,86,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[93,0,93,1],[94,0,94,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 008",null,null,null,null,"Revision",null,1]
[]
["Rugloop II© calculations validation"]
["Drug model:  Alfentanil Shafer (BSA adjusted)"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Shafer A et al.: Anesth & Analg 1986, 65, 1021-1028                                                                                      Adjustment tpeak = 1.376min: from Shafer / Varvel "]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2003-01-10"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… AFTER filling in these values, press \"Calculate K41\" button to update the K41 value to your specifications. "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for remifentanil. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp & Ce values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
["Model:",null,"Unit of concentration : ng/ml"]
[]
[null,null,"Vc = 0.825 * bsa"]
[null,null,"k10 = 0.0748"]
[null,null,"k12 = 0.515"]
[null,null,"k13 = 0.231"]
[null,null,"k21 = 0.142"]
[null,null,"k31 = 0.0185"]
[]
[]
["Patient data"]
[]
["Enter patient age",null,null,null,null,{"$f":"KPTIVA!E14","v":40},"years"]
["Enter patient weight ",null,null,null,null,{"$f":"Poids","v":70},"kg"]
["Enter patient height ",null,null,null,null,{"$f":"KPTIVA!E18","v":170},"cm"]
["Enter patient gender ",null,null,null,null,{"$f":"KPTIVA!E22","v":1},"(1 = MALE, 2 = FEMALE)"]
["Enter drug conc",null,null,null,null,{"$f":"Concentration_Rapifen","v":100},"µg/ml"]
[]
["Model covariates",null,null,null,null,null,"------>",null,null,"Model K-values"]
[null,null,null,null,"Male","Female",null,null,null,null,0.5]
["Lbm",null,{"$f":"IF((F73=1),E78,IF((F73=2),F78,1/0))","v":55.297577854671282},null,{"$f":"1.1*F71-128*F71/F72*F71/F72","v":55.297577854671282},{"$f":"1.07*F71-148*F71/F72*F71/F72","v":49.806574394463674},null,null,null,"Vc",{"$f":"0.825*C79","v":1.4930089364464298}]
["BSA",null,{"$f":"POWER(F71,0.425)*POWER(F72,0.725)*0.007184","v":1.8097078017532484},null,null,null,null,null,null,"K10",{"$f":"0.0748","v":7.4800000000000005E-2},"1/min"]
[null,null,null,null,null,null,null,null,null,"K12",{"$f":"0.515","v":0.51500000000000001},"1/min"]
[null,null,null,null,null,null,null,null,null,"K13",{"$f":"0.231","v":0.23100000000000001},"1/min"]
[null,null,null,null,null,null,null,null,null,"K21",0.14199999999999999,"1/min"]
[null,null,null,null,null,null,null,null,null,"K31",1.8499999999999999E-2,"1/min"]
[null,null,null,null,null,null,null,null,null,"K41",0.73213958740234375,"1/min"]
[]
["Tpeak",null,1.3759999999999999,"min"]
["Drug conc[µg/ml]",null,{"$f":"F74","v":100}]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation",null,null,null,null,"K41 determinations - estimate for tpeak. "]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"K78","v":1.4930089364464298},"a0",{"$f":"A_K10*A_K21*A_K31","v":9.0972037037037036E-10},{"$f":"A_K10*A_K21","v":2.9504444444444446E-6},"_","PCoef1",{"$f":"(A_K21-A_Lambda1)*(A_K31-A_Lambda1)/(A_Lambda1-A_Lambda2)/(A_Lambda1-A_Lambda3)/A_Vc/A_Lambda1","v":38.803900331835685},{"$f":"(A_K21-A_Lambda1)/(A_Lambda2-A_Lambda1)/A_Vc/A_Lambda1","v":39.441995499127501},{"$f":"1/A_Vc/A_Lambda1","v":43.701342535305123},"ECoef1",{"$f":"A_PCoef1/(A_K41-A_Lambda1)*A_K41","v":-151.5596983144811},{"$f":"J91/(A_K41-A_Lambda1)*A_K41","v":-154.05196095363991},{"$f":"K91/(A_K41-A_Lambda1)*A_K41","v":-170.68805542608493},null,"Table calculating dirac-impulse concentration result at time tpeak for a certain set of Kvalues"]
["K10",null,{"$f":"K79/60","v":1.2466666666666668E-3},"a1",{"$f":"A_K10*A_K31+A_K21*A_K31+A_K21*A_K13+A_K10*A_K21+A_K31*A_K12","v":1.582275E-5},{"$f":"(A_K10+A_K12+A_K21)","v":1.2196666666666666E-2},"_","PCoef2",{"$f":"(A_K21-A_Lambda2)*(A_K31-A_Lambda2)/(A_Lambda2-A_Lambda1)/(A_Lambda2-A_Lambda3)/A_Vc/A_Lambda2","v":49.095307140460285},{"$f":"(A_K21-A_Lambda2)/(A_Lambda1-A_Lambda2)/A_Vc/A_Lambda2","v":67.499358541375273},0,"ECoef2",{"$f":"A_PCoef2/(A_K41-A_Lambda2)*A_K41","v":53.32146407501584},{"$f":"J92/(A_K41-A_Lambda2)*A_K41","v":73.309748552004095},0,null,"When the results Ceff have a peak it is what we want. "]
["K12",null,8.5833333333333334E-3,"a2",{"$f":"A_K10+A_K12+A_K13+A_K31+A_K21","v":1.6355000000000001E-2},"_","_","PCoef3",{"$f":"(A_K21-A_Lambda3)*(A_K31-A_Lambda3)/(A_Lambda3-A_Lambda2)/(A_Lambda3-A_Lambda1)/A_Vc/A_Lambda3","v":449.36417913704707},0,0,"ECoef3",{"$f":"A_PCoef3/(A_K41-A_Lambda3)*A_K41","v":451.63574103212676},0,0,null,"If the values keep increasing, k41 must increase."]
["K13",null,3.8500000000000001E-3,"p",{"$f":"A_a1-(A_a2*A_a2/3)","v":-7.333925833333336E-5},"_","_",null,null,null,null,"ECoef4",{"$f":"(A_K41-A_K21)*(A_K41-A_K31)/(A_Lambda1-A_K41)/(A_Lambda2-A_K41)/(A_Lambda3-A_K41)/A_Vc","v":183.86587981668168},{"$f":"(A_K21-A_K41)/(A_Lambda1-A_K41)/(A_Lambda2-A_K41)/A_Vc","v":187.68356644213861},{"$f":"1/(A_Lambda1-A_K41)/A_Vc","v":214.38939796139007},null,"If the values keep decreasing, k41 must decrease."]
["K21",null,2.3666666666666667E-3,"q",{"$f":"(2*A_a2*A_a2*A_a2/27)-(A_a1*A_a2/3)+A_a0","v":2.3870372746296307E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"E1'","E2'","E3'","E4'"]
["K31",null,3.0833333333333331E-4,"r1",{"$f":"SQRT(-(A_p*A_p*A_p)/27)","v":1.2087121522571595E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"A_ECoef1*A_Lambda1","v":-2.3228787761556622},{"$f":"A_ECoef2*A_Lambda2","v":5.1568946572717489E-2},{"$f":"A_ECoef3*A_Lambda3","v":2.7718339810374963E-2},{"$f":"A_ECoef4*A_Lambda4","v":2.2435914897725708}]
["K41",null,1.220232645670573E-2,null,{"$f":"(MIN(MAX(-A_q/2/A_r1,-1),1))","v":-0.98742999736209192},null,null,null,null,"Modelling results ",null,null,null,null,null,null,null,null,"Ceff","I1'","I2'","I3'","I4'"]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-A_q/2)/A_r1,-1),1)))/3","v":0.99429003140059502},"_","_",null,null,"Lambda1",{"$f":"IF(A_K31>0,E103,IF(A_K21>0,F103,G103))","v":1.5326493797419481E-2},null,null,null,null,null,"T1",{"$f":"C86*60*0.99","v":81.734399999999994},{"$f":"T98*$T$96+U98*$U$96+V98*$V$96+W98*$W$96","v":0.23907031348674745},{"$f":"EXP(-A_Lambda1*$R$98)","v":0.28573177020912793},{"$f":"EXP(-A_Lambda2*$R$98)","v":0.92399554014924312},{"$f":"EXP(-A_Lambda3*$R$98)","v":0.99499625730434693},{"$f":"EXP(-A_Lambda4*$R$98)","v":0.3688556766853342}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(A_r1)/3)","v":9.8886641048110194E-3},"_","_",null,null,"Lambda2",{"$f":"IF(A_K31>0,E104,IF(A_K21>0,F104,G104))","v":9.6713298232335102E-4},null,null,null,null,null,"T2",{"$f":"C86*60","v":82.559999999999988},{"$f":"T99*$T$96+U99*$U$96+V99*$V$96+W99*$W$96","v":0.23908119377099102},{"$f":"EXP(-A_Lambda1*$R$99)","v":0.28213902645527228},{"$f":"EXP(-A_Lambda2*$R$99)","v":0.92325805652593596},{"$f":"EXP(-A_Lambda3*$R$99)","v":0.99494584238926309},{"$f":"EXP(-A_Lambda4*$R$99)","v":0.36515839075059481}]
["L1",{"$f":"(POWER(-E100,3)+POWER(E100,2)*A_a2-E100*A_a1+A_a0)<0.000000000000001","v":true},{"$f":"POWER(F100,2)-A__a1*F100+A__a0","v":-3.3881317890172014E-21},"L1",{"$f":"-(COS(A_Phi)*A_r1_Use-A_a2/3)","v":6.1373220257170125E-5},{"$f":"-(-A__a1+SQRT(A__a1*A__a1-4*A__a0))/2","v":2.4690402076362611E-4},{"$f":"A_K10","v":1.2466666666666668E-3},null,null,"Lambda3",{"$f":"IF(A_K31>0,E105,IF(A_K21>0,F105,G105))","v":6.1373220257170125E-5},null,null,null,null,null,"T3",{"$f":"C86*60*1.01","v":83.385599999999982},{"$f":"T100*$T$96+U100*$U$96+V100*$V$96+W100*$W$96","v":0.23907031775127496},{"$f":"EXP(-A_Lambda1*$R$100)","v":0.27859145726380913},{"$f":"EXP(-A_Lambda2*$R$100)","v":0.92252116152245556},{"$f":"EXP(-A_Lambda3*$R$100)","v":0.99489543002862468},{"$f":"EXP(-A_Lambda4*$R$100)","v":0.36149816517346217}]
["L2",{"$f":"(POWER(-E101,3)+POWER(E101,2)*A_a2-E101*A_a1+A_a0)<0.000000000000001","v":true},{"$f":"POWER(F101,2)-F101*A__a1+A__a0","v":-9.3173624197973037E-21},"L2",{"$f":"-(COS(A_Phi+PI()*2/3)*A_r1_Use-A_a2/3)","v":1.5326493797419481E-2},{"$f":"-(-A__a1-SQRT(A__a1*A__a1-4*A__a0))/2","v":1.194976264590304E-2},0,null,null,"Lambda4",{"$f":"A_K41","v":1.220232645670573E-2}]
["L3",{"$f":"(POWER(-E102,3)+POWER(E102,2)*A_a2-E102*A_a1+A_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(A_Phi+PI()*4/3)*A_r1_Use-A_a2/3)","v":9.6713298232335102E-4},0,0,null,null,"PCoef1",{"$f":"IF(A_K31>0,I91,IF(A_K21>0,J91,K91))","v":38.803900331835685}]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E100,E101),E102)","v":1.5326493797419481E-2},{"$f":"MAX(MAX(F100,F101),F102)","v":1.194976264590304E-2},{"$f":"MAX(MAX(G100,G101),G102)","v":1.2466666666666668E-3},null,null,"PCoef2",{"$f":"IF(A_K31>0,I92,IF(A_K21>0,J92,K92))","v":49.095307140460285}]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E103<>E100,E105<>E100),E100,IF(AND(E103<>E101,E105<>E101),E101,E102))","v":9.6713298232335102E-4},{"$f":"IF(AND(F103<>F100,F105<>F100),F100,IF(AND(F103<>F101,F105<>F101),F101,F102))","v":2.4690402076362611E-4},{"$f":"IF(AND(G103<>G100,G105<>G100),G100,IF(AND(G103<>G101,G105<>G101),G101,G102))","v":0},null,null,"PCoef3",{"$f":"IF(A_K31>0,I93,IF(A_K21>0,J93,K93))","v":449.36417913704707}]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E100,E101),E102)","v":6.1373220257170125E-5},{"$f":"MIN(MIN(F100,F101),F102)","v":0},{"$f":"MIN(MIN(G100,G101),G102)","v":0},null,null,"ECoef1",{"$f":"IF(A_K31>0,M91,IF(A_K21>0,N91,O91))","v":-151.5596983144811}]
[null,null,null,null,null,null,null,null,null,"ECoef2",{"$f":"IF(A_K31>0,M92,IF(A_K21>0,N92,O92))","v":53.32146407501584}]
[null,null,null,null,null,null,null,null,null,"ECoef3",{"$f":"IF(A_K31>0,M93,IF(A_K21>0,N93,O93))","v":451.63574103212676}]
[null,null,null,null,null,null,null,null,null,"ECoef4",{"$f":"IF(A_K31>0,M94,IF(A_K21>0,N94,O94))","v":183.86587981668168}]
[]
["Time","Time ","Infused volume","Cp, calculated","Ce,calculated","DeltaTime","InfusionRate","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time","25ms",null,0,5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Infused volume","mls",null,0,{"$f":"C114","v":0},{"$f":"KPTIVA!L49","v":0},{"$f":"KPTIVA!M49","v":0},{"$f":"KPTIVA!N49","v":0},{"$f":"KPTIVA!O49","v":0},{"$f":"KPTIVA!P49","v":0},{"$f":"KPTIVA!Q49","v":0},{"$f":"KPTIVA!R49","v":0},{"$f":"KPTIVA!S49","v":0},{"$f":"KPTIVA!T49","v":0},{"$f":"KPTIVA!U49","v":0},{"$f":"KPTIVA!V49","v":0},{"$f":"KPTIVA!W49","v":0},{"$f":"KPTIVA!X49","v":0},{"$f":"KPTIVA!Y49","v":0},{"$f":"KPTIVA!Z49","v":0},{"$f":"KPTIVA!AA49","v":0},{"$f":"KPTIVA!AB49","v":0},{"$f":"KPTIVA!AC49","v":0},{"$f":"KPTIVA!AD49","v":0},{"$f":"KPTIVA!AE49","v":0},{"$f":"KPTIVA!AF49","v":0},{"$f":"KPTIVA!AG49","v":0},{"$f":"KPTIVA!AH49","v":0},{"$f":"KPTIVA!AI49","v":0},{"$f":"KPTIVA!AJ49","v":0},{"$f":"KPTIVA!AK49","v":0},{"$f":"KPTIVA!AL49","v":0},{"$f":"KPTIVA!AM49","v":0},{"$f":"KPTIVA!AN49","v":0},{"$f":"KPTIVA!AO49","v":0},{"$f":"KPTIVA!AP49","v":0},{"$f":"KPTIVA!AQ49","v":0},{"$f":"KPTIVA!AR49","v":0},{"$f":"KPTIVA!AS49","v":0},{"$f":"KPTIVA!AT49","v":0},{"$f":"KPTIVA!AU49","v":0},{"$f":"KPTIVA!AV49","v":0},{"$f":"KPTIVA!AW49","v":0},{"$f":"KPTIVA!AX49","v":0},{"$f":"KPTIVA!AY49","v":0},{"$f":"KPTIVA!AZ49","v":0},{"$f":"KPTIVA!BA49","v":0},{"$f":"KPTIVA!BB49","v":0},{"$f":"KPTIVA!BC49","v":0},{"$f":"KPTIVA!BD49","v":0},{"$f":"KPTIVA!BE49","v":0},{"$f":"KPTIVA!BF49","v":0},{"$f":"KPTIVA!BG49","v":0},{"$f":"KPTIVA!BH49","v":0},{"$f":"KPTIVA!BI49","v":0},{"$f":"KPTIVA!BJ49","v":0},{"$f":"KPTIVA!BK49","v":0},{"$f":"KPTIVA!BL49","v":0},{"$f":"KPTIVA!BM49","v":0},{"$f":"KPTIVA!BN49","v":0},{"$f":"KPTIVA!BO49","v":0},{"$f":"KPTIVA!BP49","v":0},{"$f":"KPTIVA!BQ49","v":0},{"$f":"KPTIVA!BR49","v":0}]
[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,"Cp, calculated","ng/ml",null,0,{"$f":"D114","v":0},{"$f":"Y121+Y122+Y123","v":0},{"$f":"Z121+Z122+Z123","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[5,{"$f":"60*A114","v":300},{"$f":"KPTIVA!K49","v":0},{"$f":"L114+M114+N114","v":0},{"$f":"O114+P114+Q114+R114","v":0},{"$f":"B114-B113","v":300},{"$f":"IF(F114>0,(C114-C113)/F114*$C$87,#N/A)","v":0},{"$f":"EXP(-A_Lambda1*$F114)","v":1.0072481886366844E-2},{"$f":"EXP(-A_Lambda2*$F114)","v":0.74815889679511316},{"$f":"EXP(-A_Lambda3*$F114)","v":0.98175649866347048},{"$f":"EXP(-A_Lambda4*$F114)","v":2.571455931922613E-2},{"$f":"L113*H114+(1-H114)*$G114*A_PCoef1","v":0},{"$f":"M113*I114+(1-I114)*$G114*A_PCoef2","v":0},{"$f":"N113*J114+(1-J114)*$G114*A_PCoef3","v":0},{"$f":"O113*H114+(1-H114)*$G114*A_ECoef1","v":0},{"$f":"P113*I114+(1-I114)*$G114*A_ECoef2","v":0},{"$f":"Q113*J114+(1-J114)*$G114*A_ECoef3","v":0},{"$f":"R113*K114+(1-K114)*$G114*A_ECoef4","v":0},null,"Ce,calculated","ng/ml",null,0,{"$f":"E114","v":0},{"$f":"Y124+Y125+Y126+Y127","v":0},{"$f":"Z124+Z125+Z126+Z127","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[10,600,null,{"$f":"L115+M115+N115","v":0},{"$f":"O115+P115+Q115+R115","v":0},{"$f":"B115-B114","v":300},{"$f":"IF(F115>0,(C115-C114)/F115*$C$87,#N/A)","v":0},{"$f":"EXP(-A_Lambda1*$F115)","v":1.0072481886366844E-2},{"$f":"EXP(-A_Lambda2*$F115)","v":0.74815889679511316},{"$f":"EXP(-A_Lambda3*$F115)","v":0.98175649866347048},{"$f":"EXP(-A_Lambda4*$F115)","v":2.571455931922613E-2},{"$f":"L114*H115+(1-H115)*$G115*A_PCoef1","v":0},{"$f":"M114*I115+(1-I115)*$G115*A_PCoef2","v":0},{"$f":"N114*J115+(1-J115)*$G115*A_PCoef3","v":0},{"$f":"O114*H115+(1-H115)*$G115*A_ECoef1","v":0},{"$f":"P114*I115+(1-I115)*$G115*A_ECoef2","v":0},{"$f":"Q114*J115+(1-J115)*$G115*A_ECoef3","v":0},{"$f":"R114*K115+(1-K115)*$G115*A_ECoef4","v":0},null,"DeltaTime","DeltaTime,s",null,0,{"$f":"F114","v":300},{"$f":"Y111-X111","v":300},{"$f":"Z111-Y111","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"InfusionRate","InfusionRate, amt/s",null,0,{"$f":"G114","v":0},{"$f":"IF(Y115>0,(Y112-X112)/Y115*$C$87,#N/A)","v":0},{"$f":"IF(Z115>0,(Z112-Y112)/Z115*$C$87,#N/A)","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState1","PState1",null,0,{"$f":"L114","v":0},{"$f":"X121*Y117+(1-Y117)*Y$116*A_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BD121*BE117+(1-BE117)*BE$116*A_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState2","PState2",null,0,{"$f":"M114","v":0},{"$f":"X122*Y118+(1-Y118)*Y$116*A_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BD122*BE118+(1-BE118)*BE$116*A_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState3","PState3",null,0,{"$f":"N114","v":0},{"$f":"X123*Y119+(1-Y119)*Y$116*A_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BD123*BE119+(1-BE119)*BE$116*A_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState1","eState1",null,0,{"$f":"O114","v":0},{"$f":"X124*Y117+(1-Y117)*Y$116*A_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BD124*BE117+(1-BE117)*BE$116*A_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
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{"sheet":"Remi","index":10,"n_rows":127,"n_cols":82,"rows_kept":127,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[19,0,19,14],[20,4,20,7],[21,4,21,7],[21,11,21,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[27,4,27,7],[27,11,27,12],[85,0,85,1],[28,4,28,7],[28,11,28,12],[33,0,33,1],[33,2,35,14],[36,2,38,14],[39,2,41,14],[42,2,44,14],[45,2,47,14],[48,2,50,14],[51,2,53,14],[73,0,73,1],[96,0,96,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[93,0,93,1],[94,0,94,1],[95,0,95,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 002",null,null,null,null,"Revision",null,1.01]
[]
["Rugloop II© Remifentanil calculations validation"]
["Drug model:  Remifentanil Minto"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Minto et al.: Anesthesiology 1997, 86, 10 - 33\nAdditional : k41 = 0.595 – 0.007*(age – 40)   (reference : Minto et al.: Anesthesiology 1997, 86, 10 - 33)"]
[]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2002-02-01"]
[null,null,null,1.01,"Update with references",null,null,null,"TDS",null,null,"2002-02-07"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for remifentanil. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp & Ce values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
[null,null,"Unit of concentration : ng/ml"]
[null,null,"Vc = 5.1 – 0.0201*(age-40)+0.072*(lbm-55)"]
[null,null,"V2 = 9.82 - 0.0811*(age-40)+0.108*(lbm-55)",null,null,null,null,null,null,"k10 = Cl1/Vc"]
[null,null,"V3 = 5.42",null,null,null,null,null,null,"k12 = Cl2/Vc"]
[null,null,"Cl1 = 2.6-0.0162*(age-40)+0.0191*(lbm-55)",null,null,null,null,null,null,"k13 = Cl3/Vc"]
[null,null,"Cl2 = 2.05-0.0301*(age- 40)",null,null,null,null,null,null,"k21 = Cl2/Vc"]
[null,null,"Cl3 = 0.076 – 0.00113*(age – 40)",null,null,null,null,null,null,"k31 = Cl3/Vc"]
[null,null,null,null,null,null,null,null,null,"k41 = 0.595 – 0.007*(age – 40)   "]
[]
[]
[]
["Patient data"]
[]
["Enter patient age",null,null,null,null,{"$f":"KPTIVA!E14","v":40},"years"]
["Enter patient weight ",null,null,null,null,{"$f":"Poids","v":70},"kg"]
["Enter patient height ",null,null,null,null,{"$f":"KPTIVA!E18","v":170},"cm"]
["Enter patient gender ",null,null,null,null,{"$f":"KPTIVA!E22","v":1},"(1 = MALE, 2 = FEMALE)"]
["Enter drug conc",null,null,null,null,{"$f":"Concentration_Remi","v":50},"µg/ml"]
[]
["Remifentanil minto",null,null,null,null,null,"------>",null,null,"Schnider model K-values"]
[null,null,null,null,"Male","Female",null,null,null,null,0.5]
["Lbm",null,{"$f":"IF((F73=1),E78,IF((F73=2),F78,1/0))","v":55.297577854671282},null,{"$f":"1.1*F71-128*F71/F72*F71/F72","v":55.297577854671282},{"$f":"1.07*F71-148*F71/F72*F71/F72","v":49.806574394463674},null,null,null,"Vc",{"$f":"C85","v":5.1214256055363316}]
["BSA",null,{"$f":"POWER(F71,0.425)*POWER(F72,0.725)*0.007184","v":1.8097078017532484},null,null,null,null,null,null,"K10",{"$f":"$C$82/R_Vc","v":0.5087809406442303},"1/min"]
["v2",null,{"$f":"9.82-0.0811*(F70-40)+0.108*(C78-55)","v":9.8521384083044978},null,null,null,null,null,null,"K12",{"$f":"$C$83/R_Vc","v":0.40027917183526429},"1/min"]
["v3",null,5.42,null,null,null,null,null,null,"K13",{"$f":"$C$84/R_Vc","v":1.4839618077795165E-2},"1/min"]
["cl1",null,{"$f":"2.6-0.0162*(F70-40)+0.0191*(C78-55)","v":2.6056837370242216},null,null,null,null,null,null,"K21",{"$f":"$C$83/$C$80","v":0.20807665453339833},"1/min"]
["cl2",null,{"$f":"2.05-0.0301*(F70-40)","v":2.0499999999999998},null,null,null,null,null,null,"K31",{"$f":"$C$84/$C$81","v":1.4022140221402213E-2},"1/min"]
["cl3",null,{"$f":"0.076-0.00113*(F70-40)","v":7.5999999999999998E-2},null,null,null,null,null,null,"K41",{"$f":"0.595-0.007*(F70-40)","v":0.59499999999999997},"1/min"]
["Vc",null,{"$f":"5.1-0.0201*(F70-40)+0.072*(C78-55)","v":5.1214256055363316}]
["Drug conc[ug/ml]",null,{"$f":"F74","v":50}]
[]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation"]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
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["K10",null,{"$f":"K79/60","v":8.4796823440705053E-3},"a1",{"$f":"R_K10*R_K31+R_K21*R_K31+R_K21*R_K13+R_K10*R_K21+R_K31*R_K12","v":3.461607291592406E-5},{"$f":"(R_K10+R_K12+R_K21)","v":1.8618946116881547E-2},"_","PCoef2",{"$f":"(R_K21-R_Lambda2)*(R_K31-R_Lambda2)/(R_Lambda2-R_Lambda1)/(R_Lambda2-R_Lambda3)/R_Vc/R_Lambda2","v":12.103906871389583},{"$f":"(R_K21-R_Lambda2)/(R_Lambda1-R_Lambda2)/R_Vc/R_Lambda2","v":12.160424591749107},0,"ECoef2",{"$f":"R_PCoef2/(R_K41-R_Lambda2)*R_K41","v":14.741704094292468},{"$f":"J92/(R_K41-R_Lambda2)*R_K41","v":14.810538687823044},0]
["K12",null,6.671319530587738E-3,"a2",{"$f":"R_K10+R_K12+R_K13+R_K31+R_K21","v":1.9099975421868171E-2},"_","_","PCoef3",{"$f":"(R_K21-R_Lambda3)*(R_K31-R_Lambda3)/(R_Lambda3-R_Lambda2)/(R_Lambda3-R_Lambda1)/R_Vc/R_Lambda3","v":0.76969499052476464},0,0,"ECoef3",{"$f":"R_PCoef3/(R_K41-R_Lambda3)*R_K41","v":0.78768666090158046},0,0]
["K13",null,2.4732696796325276E-4,"p",{"$f":"R_a1-(R_a2*R_a2/3)","v":-8.6986947456065342E-5},"_","_",null,null,null,null,"ECoef4",{"$f":"(R_K41-R_K21)*(R_K41-R_K31)/(R_Lambda1-R_K41)/(R_Lambda2-R_K41)/(R_Lambda3-R_K41)/R_Vc","v":21.515378351472034},{"$f":"(R_K21-R_K41)/(R_Lambda1-R_K41)/(R_Lambda2-R_K41)/R_Vc","v":21.531363852207146},{"$f":"1/(R_Lambda1-R_K41)/R_Vc","v":27.185758563916693}]
["K21",null,3.4679442422233054E-3,"q",{"$f":"(2*R_a2*R_a2*R_a2/27)-(R_a1*R_a2/3)+R_a0","v":3.026203860546752E-7},"_","_"]
["K31",null,2.3370233702337022E-4,"r1",{"$f":"SQRT(-(R_p*R_p*R_p)/27)","v":1.5613463567500962E-7},"_","_"]
["K41",null,9.9166666666666656E-3,null,{"$f":"(MIN(MAX(-R_q/2/R_r1,-1),1))","v":-0.96910075316207234},null,null,null,null,"Modelling results "]
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["L2",{"$f":"(POWER(-E101,3)+POWER(E101,2)*R_a2-E101*R_a1+R_a0)<0.000000000000001","v":true},{"$f":"POWER(F101,2)-F101*R__a1+R__a0","v":0},"L2",{"$f":"-(COS(R_Phi+PI()*2/3)*R_r1_Use-R_a2/3)","v":1.709903504323761E-2},{"$f":"-(-R__a1-SQRT(R__a1*R__a1-4*R__a0))/2","v":1.6876455486386055E-2},0,null,null,"Lambda4",{"$f":"R_K41","v":9.9166666666666656E-3}]
["L3",{"$f":"(POWER(-E102,3)+POWER(E102,2)*R_a2-E102*R_a1+R_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(R_Phi+PI()*4/3)*R_r1_Use-R_a2/3)","v":1.774432292662457E-3},0,0,null,null,"PCoef1",{"$f":"IF(R_K31>0,I91,IF(R_K21>0,J91,K91))","v":10.15298388502752}]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E100,E101),E102)","v":1.709903504323761E-2},{"$f":"MAX(MAX(F100,F101),F102)","v":1.6876455486386055E-2},{"$f":"MAX(MAX(G100,G101),G102)","v":8.4796823440705053E-3},null,null,"PCoef2",{"$f":"IF(R_K31>0,I92,IF(R_K21>0,J92,K92))","v":12.103906871389583}]
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[]
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{"sheet":"KetOFA","index":11,"n_rows":121,"n_cols":82,"rows_kept":121,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[19,0,19,14],[20,4,20,7],[21,4,21,7],[21,11,21,12],[28,4,28,7],[28,11,28,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[27,4,27,7],[27,11,27,12],[33,0,33,1],[33,2,35,14],[36,2,38,14],[80,0,80,1],[42,2,44,14],[45,2,47,14],[48,2,50,14],[51,2,53,14],[58,2,58,3],[59,2,59,3],[60,2,60,3],[61,2,61,3],[62,2,62,3],[63,2,63,3],[70,0,70,1],[39,2,41,14],[91,0,91,1],[85,0,85,1],[86,0,86,1],[87,0,87,1],[88,0,88,1],[89,0,89,1],[90,0,90,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 004",null,null,null,null,"Revision",null,1]
[]
["Rugloop II© Ketamine calculations validation"]
["Drug model:  Domino et al"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Domino et al.: Clin. Pharmacol Ther 1991, 36, 645-653"]
[]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2002-07-18"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for ketamine. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
[null,null,"Unit of concentration : µg/ml"]
[null,null,"Vc = 0.063*mass"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Patient data"]
[]
["Enter patient weight ",null,null,null,null,{"$f":"OFA!Poids","v":60},"kg"]
["Enter drug conc",null,null,null,null,{"$f":"OFA!Concentration_Ketamine","v":10},"mg/ml"]
[]
[]
[null,null,null,"Vc",{"$f":"0.063*F70","v":3.7800000000000002}]
[null,null,null,"K10",0.438,"1/min"]
[null,null,null,"K12",{"$f":" 0.592","v":0.59199999999999997},"1/min"]
[null,null,null,"K13",{"$f":" 0.59","v":0.59},"1/min"]
[null,null,null,"K21",0.247,"1/min"]
[null,null,null,"K31",1.46E-2,"1/min"]
[]
["Drug conc[mg/ml]",null,{"$f":"F71","v":10}]
[]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation"]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"E74","v":3.7800000000000002},"a0",{"$f":"K_K10*K_K21*K_K31","v":7.3125722222222229E-9},{"$f":"K_K10*K_K21","v":3.0051666666666669E-5},"_","PCoef1",{"$f":"(K_K21-K_Lambda1)*(K_K31-K_Lambda1)/(K_Lambda1-K_Lambda2)/(K_Lambda1-K_Lambda3)/K_PK_Vc/K_Lambda1","v":8.6047871049982483},{"$f":"(K_K21-K_Lambda1)/(K_Lambda2-K_Lambda1)/K_PK_Vc/K_Lambda1","v":8.6478417966284198},{"$f":"1/K_PK_Vc/K_Lambda1","v":9.2068867649398829}]
["K10",null,{"$f":"E75/60","v":7.3000000000000001E-3},"a1",{"$f":"K_K10*K_K31+K_K21*K_K31+K_K21*K_K13+K_K10*K_K21+K_K31*K_K12","v":7.5711166666666681E-5},{"$f":"(K_K10+K_K12+K_K21)","v":2.1283333333333335E-2},"_","PCoef2",{"$f":"(K_K21-K_Lambda2)*(K_K31-K_Lambda2)/(K_Lambda2-K_Lambda1)/(K_Lambda2-K_Lambda3)/K_PK_Vc/K_Lambda2","v":5.9871160244548136},{"$f":"(K_K21-K_Lambda2)/(K_Lambda1-K_Lambda2)/K_PK_Vc/K_Lambda2","v":6.3611378030043237},0]
["K12",null,{"$f":"E76/60","v":9.8666666666666659E-3},"a2",{"$f":"K_K10+K_K12+K_K13+K_K31+K_K21","v":3.1359999999999999E-2},"_","_","PCoef3",{"$f":"(K_K21-K_Lambda3)*(K_K31-K_Lambda3)/(K_Lambda3-K_Lambda2)/(K_Lambda3-K_Lambda1)/K_PK_Vc/K_Lambda3","v":21.64785913770443},0,0]
["K13",null,{"$f":"E77/60","v":9.8333333333333328E-3},"p",{"$f":"K_a1-(K_a2*K_a2/3)","v":-2.5210536666666662E-4},"_","_"]
["K21",null,{"$f":"E78/60","v":4.1166666666666669E-3},"q",{"$f":"(2*K_a2*K_a2*K_a2/27)-(K_a1*K_a2/3)+K_a0","v":1.5003955067407405E-6},"_","_"]
["K31",null,{"$f":"E79/60","v":2.4333333333333333E-4},"r1",{"$f":"SQRT(-(K_p*K_p*K_p)/27)","v":7.703556179473801E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"Ctrl F3",null,"permet de renommer tous les noms d'une feuille"]
[null,null,null,null,null,null,null,null,null,"Modelling results "]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-K_q/2)/K_r1,-1),1)))/3","v":0.97077492325387194},"_","_",null,null,"Lambda1",{"$f":"IF(K_K31>0,E98,IF(K_K21>0,F98,G98))","v":2.8733954408745453E-2}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(K_r1)/3)","v":1.8334134527947837E-2},"_","_",null,null,"Lambda2",{"$f":"IF(K_K31>0,E99,IF(K_K21>0,F99,G99))","v":2.5252671973736273E-3}]
["L1",{"$f":"(POWER(-E95,3)+POWER(E95,2)*K_a2-E95*K_a1+K_a0)<0.000000000000001","v":true},{"$f":"POWER(F95,2)-K__a1*F95+K__a0","v":0},"L1",{"$f":"-(COS(K_Phi)*K_r1_Use-K_a2/3)","v":1.0077839388092369E-4},{"$f":"-(-K__a1+SQRT(K__a1*K__a1-4*K__a0))/2","v":1.5206249072086068E-3},{"$f":"K_K10","v":7.3000000000000001E-3},null,null,"Lambda3",{"$f":"IF(K_K31>0,E100,IF(K_K21>0,F100,G100))","v":1.0077839388092369E-4}]
["L2",{"$f":"(POWER(-E96,3)+POWER(E96,2)*K_a2-E96*K_a1+K_a0)<0.000000000000001","v":true},{"$f":"POWER(F96,2)-F96*K__a1+K__a0","v":0},"L2",{"$f":"-(COS(K_Phi+PI()*2/3)*K_r1_Use-K_a2/3)","v":2.8733954408745453E-2},{"$f":"-(-K__a1-SQRT(K__a1*K__a1-4*K__a0))/2","v":1.976270842612473E-2},0]
["L3",{"$f":"(POWER(-E97,3)+POWER(E97,2)*K_a2-E97*K_a1+K_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(K_Phi+PI()*4/3)*K_r1_Use-K_a2/3)","v":2.5252671973736273E-3},0,0,null,null,"PCoef1",{"$f":"IF(K_K31>0,I86,IF(K_K21>0,J86,K86))","v":8.6047871049982483},null,null,null,null,null,null,null,null,null,null,"Colonne des zéros"]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E95,E96),E97)","v":2.8733954408745453E-2},{"$f":"MAX(MAX(F95,F96),F97)","v":1.976270842612473E-2},{"$f":"MAX(MAX(G95,G96),G97)","v":7.3000000000000001E-3},null,null,"PCoef2",{"$f":"IF(K_K31>0,I87,IF(K_K21>0,J87,K87))","v":5.9871160244548136}]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E98<>E95,E100<>E95),E95,IF(AND(E98<>E96,E100<>E96),E96,E97))","v":2.5252671973736273E-3},{"$f":"IF(AND(F98<>F95,F100<>F95),F95,IF(AND(F98<>F96,F100<>F96),F96,F97))","v":1.5206249072086068E-3},{"$f":"IF(AND(G98<>G95,G100<>G95),G95,IF(AND(G98<>G96,G100<>G96),G96,G97))","v":0},null,null,"PCoef3",{"$f":"IF(K_K31>0,I88,IF(K_K21>0,J88,K88))","v":21.64785913770443},null,null,null,null,null,null,null,null,null,null,"Colonne liée à la première ligne de formules"]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E95,E96),E97)","v":1.0077839388092369E-4},{"$f":"MIN(MIN(F95,F96),F97)","v":0},{"$f":"MIN(MIN(G95,G96),G97)","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Première colonne de formules"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Les autres colonnes sont des recopies à dte"]
[]
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[0,{"$f":"A108*60","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,"Cp, calculated","µg/ml",null,0,{"$f":"D109","v":0},{"$f":"X115+X116+X117","v":0},{"$f":"Y115+Y116+Y117","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[5,{"$f":"A109*60","v":300},{"$f":"OFA!K32","v":0},{"$f":"K109+L109+M109","v":0},{"$f":"B109-B108","v":300},{"$f":"(C109-C108)/E109*$C$81","v":0},{"$f":"EXP(-K_Lambda1*$E109)","v":1.8042663400517567E-4},{"$f":"EXP(-K_Lambda2*$E109)","v":0.46879947565089014},{"$f":"EXP(-K_Lambda3*$E109)","v":0.97021894334647674},{"$f":"EXP(-K_Lambda4*$E109)","v":1},{"$f":"K108*G109+(1-G109)*$F109*K_PCoef1","v":0},{"$f":"L108*H109+(1-H109)*$F109*K_PCoef2","v":0},{"$f":"M108*I109+(1-I109)*$F109*K_PCoef3","v":0},{"$f":"N108*G109+(1-G109)*$F109*K_ECoef1","v":0},{"$f":"O108*H109+(1-H109)*$F109*K_ECoef2","v":0},{"$f":"P108*I109+(1-I109)*$F109*K_ECoef3","v":0},{"$f":"Q108*J109+(1-J109)*$F109*K_ECoef4","v":0},null,"DeltaTime","DeltaTime,s",null,0,{"$f":"E109","v":300},{"$f":"X106-W106","v":300},{"$f":"Y106-X106","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
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[null,null,null,"la colonne Ce a été retirée",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I4","I4",null,0,{"$f":"J109","v":1},{"$f":"EXP(-K_Lambda4*X$109)","v":1},1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,{"$f":"EXP(-K_Lambda4*BD$109)","v":1},1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState3","eState3",null,0,{"$f":"P109","v":0},{"$f":"W120*X113+(1-X113)*X$110*K_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC120*BD113+(1-BD113)*BD$110*K_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState4","eState4",null,0,{"$f":"Q109","v":0},{"$f":"W121*X114+(1-X114)*X$110*K_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC121*BD114+(1-BD114)*BD$110*K_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"ProFA","index":12,"n_rows":127,"n_cols":82,"rows_kept":127,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[18,0,18,14],[19,4,19,7],[20,4,20,7],[20,11,20,12],[21,4,21,7],[21,11,21,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[73,0,73,1],[27,4,27,7],[27,11,27,12],[34,0,34,1],[34,2,36,14],[37,2,39,14],[40,2,42,14],[43,2,45,14],[46,2,48,14],[49,2,51,14],[52,2,54,14],[57,0,57,1],[95,0,95,1],[96,0,96,1],[86,0,86,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[93,0,93,1],[94,0,94,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 001",null,null,null,null,"Revision",null,1.01]
[]
["Rugloop II© Propofol calculations validation"]
["Drug model:  Propofol Schnider"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : Schnider et al.: Anesthesiology 1998, 88, 1170-1182\nAdjustment tpeak = 1.6min: Schnider et al.: “The influence of age on propofol pharmacodynamics”, Anesthesiology, 1999, 90,1502-1516\n"]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2002-02-01"]
[null,null,null,1.01,"Update with references",null,null,null,"TDS",null,null,"2002-02-07"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… REMEMBER: press the CalculateK41 button after entering your patient's data to match the k41 with the specified patient data. "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for remifentanil. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp & Ce values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
["Model:",null,"Unit of concentration : µg/ml"]
[]
[null,null,"Vc = 4.27"]
[null,null,"V2 = 18.9 – 0.391 * (age – 53)",null,null,null,null,null,null,null,null,"k10 = Cl 1/ Vc"]
[null,null,"V3 = 238",null,null,null,null,null,null,null,null,"k12 =  Cl 2/Vc"]
[null,null,"Cl 1 = 1.89 + 0.0456 * (mass – 77) – 0.0681 * (lbm – 59) + 0.0264 * (height – 177)",null,null,null,null,null,null,null,null,"k13 = Cl 3/Vc"]
[null,null,"Cl 2 = 1.29 – 0.024 * (age – 53)",null,null,null,null,null,null,null,null,"k21 = Cl 2/ V2"]
[null,null,"Cl 3 = 0.836",null,null,null,null,null,null,null,null,"k31 = Cl 3/V3"]
[]
[]
["Patient data",null,null,null,null,"Les entrées viennent de OFA"]
[]
["Enter patient age",null,null,null,null,{"$f":"OFA!E14","v":40},"years"]
["Enter patient weight ",null,null,null,null,{"$f":"OFA!Poids","v":60},"kg"]
["Enter patient height ",null,null,null,null,{"$f":"OFA!E18","v":160},"cm"]
["Enter patient gender ",null,null,null,null,{"$f":"OFA!E22","v":2},"(1 = MALE, 2 = FEMALE)"]
["Enter drug conc",null,null,null,null,{"$f":"OFA!Concentration_propofol","v":10},"mg/ml"]
[]
["Schnider model covariates",null,null,null,null,null,"------>",null,null,"Schnider model K-values"]
[null,null,null,null,"Male","Female",null,null,null,null,0.5]
["Lbm",null,{"$f":"IF((F73=1),E78,IF((F73=2),F78,1/0))","v":43.387500000000003},null,{"$f":"1.1*F71-128*F71/F72*F71/F72","v":48},{"$f":"1.07*F71-148*F71/F72*F71/F72","v":43.387500000000003},null,null,null,"Vc",4.2699999999999996]
["BSA",null,{"$f":"POWER(F71,0.425)*POWER(F72,0.725)*0.007184","v":1.6220625314357542},null,null,null,null,null,null,"K10",{"$f":"$C$82/P_Vc","v":0.4049675058548009},"1/min"]
["v2",null,{"$f":"18.9-0.391*(F70-53)","v":23.982999999999997},null,null,null,null,null,null,"K12",{"$f":"$C$83/P_Vc","v":0.37517564402810311},"1/min"]
["v3",null,238,null,null,null,null,null,null,"K13",{"$f":"$C$84/P_Vc","v":0.19578454332552694},"1/min"]
["cl1",null,{"$f":"1.89+0.0456*(F71-77)-0.0681*(C78-59)+0.0264*(F72-177)","v":1.7292112499999996},null,null,null,null,null,null,"K21",{"$f":"$C$83/$C$80","v":6.6797314764624957E-2},"1/min"]
["cl2",null,{"$f":"1.29-0.024*(F70-53)","v":1.6020000000000001},null,null,null,null,null,null,"K31",{"$f":"$C$84/$C$81","v":3.5126050420168065E-3},"1/min"]
["cl3",null,0.83599999999999997,null,null,null,null,null,null,"K41",0.33877944946289063,"1/min"]
["Vc",null,4.2699999999999996]
["Tpeak",null,1.6,"min"]
["Drug conc[mg/ml]",null,{"$f":"F74","v":10}]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation",null,null,null,null,"K41 determinations - estimate for tpeak. "]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"K78","v":4.2699999999999996},"a0",{"$f":"P_K10*P_K21*P_K31","v":4.3990079903734054E-10},{"$f":"P_K10*P_K21","v":7.5140949883411762E-6},"_","PCoef1",{"$f":"(P_K21-P_Lambda1)*(P_K31-P_Lambda1)/(P_Lambda1-P_Lambda2)/(P_Lambda1-P_Lambda3)/P_Vc/P_Lambda1","v":13.606194989395199},{"$f":"(P_K21-P_Lambda1)/(P_Lambda2-P_Lambda1)/P_Vc/P_Lambda1","v":13.62219742218192},{"$f":"1/P_Vc/P_Lambda1","v":14.004281383452804},"ECoef1",{"$f":"P_PCoef1/(P_K41-P_Lambda1)*P_K41","v":-6.9358137062509808},{"$f":"J91/(P_K41-P_Lambda1)*P_K41","v":-6.9439710120033977},{"$f":"K91/(P_K41-P_Lambda1)*P_K41","v":-7.1387398785077192},null,"Table calculating dirac-impulse concentration result at time tpeak for a certain set of Kvalues"]
["K10",null,{"$f":"K79/60","v":6.7494584309133483E-3},"a1",{"$f":"P_K10*P_K31+P_K21*P_K31+P_K21*P_K13+P_K10*P_K21+P_K31*P_K12","v":1.1973219741944661E-5},{"$f":"(P_K10+P_K12+P_K21)","v":1.4115674410792148E-2},"_","PCoef2",{"$f":"(P_K21-P_Lambda2)*(P_K31-P_Lambda2)/(P_Lambda2-P_Lambda1)/(P_Lambda2-P_Lambda3)/P_Vc/P_Lambda2","v":9.1682685327727427},{"$f":"(P_K21-P_Lambda2)/(P_Lambda1-P_Lambda2)/P_Vc/P_Lambda2","v":9.4595400124937949},0,"ECoef2",{"$f":"P_PCoef2/(P_K41-P_Lambda2)*P_K41","v":10.414089331233518},{"$f":"J92/(P_K41-P_Lambda2)*P_K41","v":10.74493993826065},0,null,"When the results Ceff have a peak it is what we want. "]
["K12",null,6.2529274004683852E-3,"a2",{"$f":"P_K10+P_K12+P_K13+P_K31+P_K21","v":1.7437293550251212E-2},"_","_","PCoef3",{"$f":"(P_K21-P_Lambda3)*(P_K31-P_Lambda3)/(P_Lambda3-P_Lambda2)/(P_Lambda3-P_Lambda1)/P_Vc/P_Lambda3","v":11.923437037988768},0,0,"ECoef3",{"$f":"P_PCoef3/(P_K41-P_Lambda3)*P_K41","v":12.006247431830317},0,0,null,"If the values keep increasing, k41 must increase."]
["K13",null,3.2630757220921155E-3,"p",{"$f":"P_a1-(P_a2*P_a2/3)","v":-8.9379849043932843E-5},"_","_",null,null,null,null,"ECoef4",{"$f":"(P_K41-P_K21)*(P_K41-P_K31)/(P_Lambda1-P_K41)/(P_Lambda2-P_K41)/(P_Lambda3-P_K41)/P_Vc","v":19.213377503343864},{"$f":"(P_K21-P_K41)/(P_Lambda1-P_K41)/(P_Lambda2-P_K41)/P_Vc","v":19.280768508418465},{"$f":"1/(P_Lambda1-P_K41)/P_Vc","v":21.143021261960527},null,"If the values keep decreasing, k41 must decrease."]
["K21",null,1.113288579410416E-3,"q",{"$f":"(2*P_a2*P_a2*P_a2/27)-(P_a1*P_a2/3)+P_a0","v":3.235848767024198E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"E1'","E2'","E3'","E4'"]
["K31",null,5.8543417366946774E-5,"r1",{"$f":"SQRT(-(P_p*P_p*P_p)/27)","v":1.6262134293570028E-7},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"P_ECoef1*P_Lambda1","v":-0.11598683994621542},{"$f":"P_ECoef2*P_Lambda2","v":7.0343080705326739E-3},{"$f":"P_ECoef3*P_Lambda3","v":4.6757432725742028E-4},{"$f":"P_ECoef4*P_Lambda4","v":0.10848495754842538}]
["K41",null,5.6463241577148441E-3,null,{"$f":"(MIN(MAX(-P_q/2/P_r1,-1),1))","v":-0.99490285488038233},null,null,null,null,"Modelling results ",null,null,null,null,null,null,null,null,"Ceff","I1'","I2'","I3'","I4'"]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-P_q/2)/P_r1,-1),1)))/3","v":1.0135276465237801},"_","_",null,null,"Lambda1",{"$f":"IF(P_K31>0,E103,IF(P_K21>0,F103,G103))","v":1.6722888598014241E-2},null,null,null,null,null,"T1",{"$f":"C86*60*0.99","v":95.039999999999992},{"$f":"T98*$T$96+U98*$U$96+V98*$V$96+W98*$W$96","v":4.6827587886203316E-2},{"$f":"EXP(-P_Lambda1*$R$98)","v":0.20405956706262179},{"$f":"EXP(-P_Lambda2*$R$98)","v":0.93782137025742329},{"$f":"EXP(-P_Lambda3*$R$98)","v":0.99630557950266063},{"$f":"EXP(-P_Lambda4*$R$98)","v":0.5847173868107558}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(P_r1)/3)","v":1.0916644725307182E-2},"_","_",null,null,"Lambda2",{"$f":"IF(P_K31>0,E104,IF(P_K21>0,F104,G104))","v":6.7546070009555804E-4},null,null,null,null,null,"T2",{"$f":"C86*60","v":96},{"$f":"T99*$T$96+U99*$U$96+V99*$V$96+W99*$W$96","v":4.6857322644949143E-2},{"$f":"EXP(-P_Lambda1*$R$99)","v":0.20080975625664896},{"$f":"EXP(-P_Lambda2*$R$99)","v":0.93721344436100384},{"$f":"EXP(-P_Lambda3*$R$99)","v":0.99626833183827446},{"$f":"EXP(-P_Lambda4*$R$99)","v":0.58155651750020765}]
["L1",{"$f":"(POWER(-E100,3)+POWER(E100,2)*P_a2-E100*P_a1+P_a0)<0.000000000000001","v":true},{"$f":"POWER(F100,2)-P__a1*F100+P__a0","v":0},"L1",{"$f":"-(COS(P_Phi)*P_r1_Use-P_a2/3)","v":3.8944252141415343E-5},{"$f":"-(-P__a1+SQRT(P__a1*P__a1-4*P__a0))/2","v":5.5407129405425463E-4},{"$f":"P_K10","v":6.7494584309133483E-3},null,null,"Lambda3",{"$f":"IF(P_K31>0,E105,IF(P_K21>0,F105,G105))","v":3.8944252141415343E-5},null,null,null,null,null,"T3",{"$f":"C86*60*1.01","v":96.960000000000008},{"$f":"T100*$T$96+U100*$U$96+V100*$V$96+W100*$W$96","v":4.6882910870180011E-2},{"$f":"EXP(-P_Lambda1*$R$100)","v":0.19761170127093311},{"$f":"EXP(-P_Lambda2*$R$100)","v":0.93660591254165182},{"$f":"EXP(-P_Lambda3*$R$100)","v":0.99623108556642126},{"$f":"EXP(-P_Lambda4*$R$100)","v":0.57841273523893111}]
["L2",{"$f":"(POWER(-E101,3)+POWER(E101,2)*P_a2-E101*P_a1+P_a0)<0.000000000000001","v":true},{"$f":"POWER(F101,2)-F101*P__a1+P__a0","v":-1.4399560103323106E-20},"L2",{"$f":"-(COS(P_Phi+PI()*2/3)*P_r1_Use-P_a2/3)","v":1.6722888598014241E-2},{"$f":"-(-P__a1-SQRT(P__a1*P__a1-4*P__a0))/2","v":1.3561603116737894E-2},0,null,null,"Lambda4",{"$f":"P_K41","v":5.6463241577148441E-3},null,null,null,null,null,null,null,null,null,null,null,null,"Colonne des zéros"]
["L3",{"$f":"(POWER(-E102,3)+POWER(E102,2)*P_a2-E102*P_a1+P_a0)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(P_Phi+PI()*4/3)*P_r1_Use-P_a2/3)","v":6.7546070009555804E-4},0,0,null,null,"PCoef1",{"$f":"IF(P_K31>0,I91,IF(P_K21>0,J91,K91))","v":13.606194989395199}]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E100,E101),E102)","v":1.6722888598014241E-2},{"$f":"MAX(MAX(F100,F101),F102)","v":1.3561603116737894E-2},{"$f":"MAX(MAX(G100,G101),G102)","v":6.7494584309133483E-3},null,null,"PCoef2",{"$f":"IF(P_K31>0,I92,IF(P_K21>0,J92,K92))","v":9.1682685327727427},null,null,null,null,null,null,null,null,null,null,null,null,"Colonne liée à la première ligne de formules"]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E103<>E100,E105<>E100),E100,IF(AND(E103<>E101,E105<>E101),E101,E102))","v":6.7546070009555804E-4},{"$f":"IF(AND(F103<>F100,F105<>F100),F100,IF(AND(F103<>F101,F105<>F101),F101,F102))","v":5.5407129405425463E-4},{"$f":"IF(AND(G103<>G100,G105<>G100),G100,IF(AND(G103<>G101,G105<>G101),G101,G102))","v":0},null,null,"PCoef3",{"$f":"IF(P_K31>0,I93,IF(P_K21>0,J93,K93))","v":11.923437037988768}]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E100,E101),E102)","v":3.8944252141415343E-5},{"$f":"MIN(MIN(F100,F101),F102)","v":0},{"$f":"MIN(MIN(G100,G101),G102)","v":0},null,null,"ECoef1",{"$f":"IF(P_K31>0,M91,IF(P_K21>0,N91,O91))","v":-6.9358137062509808},null,"Ctrl F3","permet de renommer tous les noms d'une feuille",null,null,null,null,null,null,null,null,null,"Première colonne de formules copiée par transposition de l'horizontale bleue"]
[null,null,null,null,null,null,null,null,null,"ECoef2",{"$f":"IF(P_K31>0,M92,IF(P_K21>0,N92,O92))","v":10.414089331233518}]
[null,null,null,null,null,null,null,null,null,"ECoef3",{"$f":"IF(P_K31>0,M93,IF(P_K21>0,N93,O93))","v":12.006247431830317},null,null,null,null,null,null,null,null,null,null,null,null,"Les autres colonnes sont des recopies à dte"]
[null,null,null,null,null,null,null,null,null,"ECoef4",{"$f":"IF(P_K31>0,M94,IF(P_K21>0,N94,O94))","v":19.213377503343864}]
[]
["Time","Time ","Infused volume","Cp, calculated","Ce,calculated","DeltaTime","InfusionRate","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time","MINUTES",0,5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300]
["MINUTES","s","mls","µg/ml","µg/ml","DeltaTime,s","InfusionRate, amt/s","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time ","s",0,{"$f":"W110*60","v":300},{"$f":"X110*60","v":600},900,1200,1500,1800,2100,2400,2700,3000,3300,3600,3900,4200,4500,4800,5100,5400,5700,6000,6300,6600,6900,7200,7500,7800,8100,8400,8700,9000,9300,9600,9900,10200,10500,10800,11100,11400,11700,12000,12300,12600,12900,13200,13500,13800,14100,14400,14700,15000,15300,15600,15900,16200,16500,16800,17100,17400,17700,18000]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Infused volume","mls",0,{"$f":"OFA!K37","v":0},{"$f":"OFA!L37","v":0},{"$f":"OFA!M37","v":0},{"$f":"OFA!N37","v":0},{"$f":"OFA!O37","v":0},{"$f":"OFA!P37","v":0},{"$f":"OFA!Q37","v":0},{"$f":"OFA!R37","v":0},{"$f":"OFA!S37","v":0},{"$f":"OFA!T37","v":0},{"$f":"OFA!U37","v":0},{"$f":"OFA!V37","v":0},{"$f":"OFA!W37","v":0},{"$f":"OFA!X37","v":0},{"$f":"OFA!Y37","v":0},{"$f":"OFA!Z37","v":0},{"$f":"OFA!AA37","v":0},{"$f":"OFA!AB37","v":0},{"$f":"OFA!AC37","v":0},{"$f":"OFA!AD37","v":0},{"$f":"OFA!AE37","v":0},{"$f":"OFA!AF37","v":0},{"$f":"OFA!AG37","v":0},{"$f":"OFA!AH37","v":0},{"$f":"OFA!AI37","v":0},{"$f":"OFA!AJ37","v":0},{"$f":"OFA!AK37","v":0},{"$f":"OFA!AL37","v":0},{"$f":"OFA!AM37","v":0},{"$f":"OFA!AN37","v":0},{"$f":"OFA!AO37","v":0},{"$f":"OFA!AP37","v":0},{"$f":"OFA!AQ37","v":0},{"$f":"OFA!AR37","v":0},{"$f":"OFA!AS37","v":0},{"$f":"OFA!AT37","v":0},{"$f":"OFA!AU37","v":0},{"$f":"OFA!AV37","v":0},{"$f":"OFA!AW37","v":0},{"$f":"OFA!AX37","v":0},{"$f":"OFA!AY37","v":0},{"$f":"OFA!AZ37","v":0},{"$f":"OFA!BA37","v":0},{"$f":"OFA!BB37","v":0},{"$f":"OFA!BC37","v":0},{"$f":"OFA!BD37","v":0},{"$f":"OFA!BE37","v":0},{"$f":"OFA!BF37","v":0},{"$f":"OFA!BG37","v":0},{"$f":"OFA!BH37","v":0},{"$f":"OFA!BI37","v":0},{"$f":"OFA!BJ37","v":0},{"$f":"OFA!BK37","v":0},{"$f":"OFA!BL37","v":0},{"$f":"OFA!BM37","v":0},{"$f":"OFA!BN37","v":0},{"$f":"OFA!BO37","v":0},{"$f":"OFA!BP37","v":0},{"$f":"OFA!BQ37","v":0},{"$f":"OFA!BR37","v":0}]
[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,"Cp, calculated","µg/ml",0,{"$f":"D114","v":0},{"$f":"X121+X122+X123","v":0},{"$f":"Y121+Y122+Y123","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[5,{"$f":"A114*60","v":300},{"$f":"OFA!K37","v":0},{"$f":"L114+M114+N114","v":0},{"$f":"O114+P114+Q114+R114","v":0},{"$f":"B114-B113","v":300},{"$f":"(C114-C113)/F114*$C$87","v":0},{"$f":"EXP(-P_Lambda1*$F114)","v":6.6252539259156274E-3},{"$f":"EXP(-P_Lambda2*$F114)","v":0.81657361613575685},{"$f":"EXP(-P_Lambda3*$F114)","v":0.98838470880452811},{"$f":"EXP(-P_Lambda4*$F114)","v":0.18380180524579801},{"$f":"L113*H114+(1-H114)*$G114*P_PCoef1","v":0},{"$f":"M113*I114+(1-I114)*$G114*P_PCoef2","v":0},{"$f":"N113*J114+(1-J114)*$G114*P_PCoef3","v":0},{"$f":"O113*H114+(1-H114)*$G114*P_ECoef1","v":0},{"$f":"P113*I114+(1-I114)*$G114*P_ECoef2","v":0},{"$f":"Q113*J114+(1-J114)*$G114*P_ECoef3","v":0},{"$f":"R113*K114+(1-K114)*$G114*P_ECoef4","v":0},null,"Ce,calculated","µg/ml",0,{"$f":"E114","v":0},{"$f":"X124+X125+X126+X127","v":0},{"$f":"Y124+Y125+Y126+Y127","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[10,{"$f":"A115*60","v":600},20,{"$f":"L115+M115+N115","v":10.224164686089923},7.2278244409659917,{"$f":"B115-B114","v":300},{"$f":"(C115-C114)/F115*$C$87","v":0.66666666666666663},6.6252539259156274E-3,0.81657361613575685,0.98838470880452811,0.18380180524579801,{"$f":"L114*H115+(1-H115)*$G115*P_PCoef1","v":9.0107003284166236},1.1211348955085563,9.2329462164742901E-2,-4.5932414528428147,1.2734791648449055,9.2970706723730437E-2,10.45461602224017,null,"DeltaTime","DeltaTime,s",0,{"$f":"F114","v":300},{"$f":"X111-W111","v":300},{"$f":"Y111-X111","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"InfusionRate","InfusionRate, amt/s",0,{"$f":"G114","v":0},{"$f":"(X112-W112)/X115*$C$87","v":0},{"$f":"(Y112-X112)/Y115*$C$87","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I1","I1",0,{"$f":"H114","v":6.6252539259156274E-3},{"$f":"EXP(-P_Lambda1*X$115)","v":6.6252539259156274E-3},6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,{"$f":"EXP(-P_Lambda1*BD$115)","v":6.6252539259156274E-3},6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3,6.6252539259156274E-3]
[null,"4 colonnes ont été retirées (comparaisons)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I2","I2",0,{"$f":"I114","v":0.81657361613575685},{"$f":"EXP(-P_Lambda2*X$115)","v":0.81657361613575685},0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,{"$f":"EXP(-P_Lambda2*BD$115)","v":0.81657361613575685},0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685,0.81657361613575685]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I3","I3",0,{"$f":"J114","v":0.98838470880452811},{"$f":"EXP(-P_Lambda3*X$115)","v":0.98838470880452811},0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,{"$f":"EXP(-P_Lambda3*BD$115)","v":0.98838470880452811},0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811,0.98838470880452811]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"I4","I4",0,{"$f":"K114","v":0.18380180524579801},{"$f":"EXP(-P_Lambda4*X$115)","v":0.18380180524579801},0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,{"$f":"EXP(-P_Lambda4*BD$115)","v":0.18380180524579801},0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801,0.18380180524579801]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState1","PState1",0,{"$f":"L114","v":0},{"$f":"W121*X117+(1-X117)*X$116*P_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC121*BD117+(1-BD117)*BD$116*P_PCoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState2","PState2",0,{"$f":"M114","v":0},{"$f":"W122*X118+(1-X118)*X$116*P_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC122*BD118+(1-BD118)*BD$116*P_PCoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PState3","PState3",0,{"$f":"N114","v":0},{"$f":"W123*X119+(1-X119)*X$116*P_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC123*BD119+(1-BD119)*BD$116*P_PCoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState1","eState1",0,{"$f":"O114","v":0},{"$f":"W124*X117+(1-X117)*X$116*P_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC124*BD117+(1-BD117)*BD$116*P_ECoef1","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState2","eState2",0,{"$f":"P114","v":0},{"$f":"W125*X118+(1-X118)*X$116*P_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC125*BD118+(1-BD118)*BD$116*P_ECoef2","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState3","eState3",0,{"$f":"Q114","v":0},{"$f":"W126*X119+(1-X119)*X$116*P_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC126*BD119+(1-BD119)*BD$116*P_ECoef3","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"eState4","eState4",0,{"$f":"R114","v":0},{"$f":"W127*X120+(1-X120)*X$116*P_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"BC127*BD120+(1-BD120)*BD$116*P_ECoef4","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"Dexmed","index":13,"n_rows":127,"n_cols":82,"rows_kept":127,"cut":false,"hidden":true,"merged":[[8,0,9,14],[3,2,3,4],[3,5,3,9],[3,10,3,11],[5,0,5,14],[6,0,6,14],[11,0,12,14],[14,0,15,14],[18,0,18,14],[19,4,19,7],[20,4,20,7],[20,11,20,12],[21,4,21,7],[21,11,21,12],[22,4,22,7],[22,11,22,12],[23,4,23,7],[23,11,23,12],[24,4,24,7],[24,11,24,12],[25,4,25,7],[25,11,25,12],[26,4,26,7],[26,11,26,12],[73,0,73,1],[27,4,27,7],[27,11,27,12],[34,0,34,1],[34,2,36,14],[37,2,39,14],[40,2,42,14],[43,2,45,14],[46,2,48,14],[49,2,51,14],[52,2,54,14],[57,0,57,1],[95,0,95,1],[96,0,96,1],[86,0,86,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[93,0,93,1],[94,0,94,1]]}
[]
[]
[]
[null,null,"Document n.",null,null,"001/006 002 012",null,null,null,null,"Revision",null,1]
[]
["Rugloop II© calculations validation"]
["Drug model:  Dexmedetomidine Dyck (weight adjusted)"]
[]
["This spreadsheet will calculate the resulting Cp & Ce, starting from the Vc-k41, and the infused volume. Fill in the boxed rectangles, and you are ready to compare the concentration as calculated by your program with the values as calculated by the spreadsheet. "]
[]
[]
["REMARK: this spreadsheet is for information purpose only, and should NOT be used to derive therapeutical decisions! This file is delivered AS IS, without guarantee for reliability. "]
[]
[]
["Reference from the literature : J.B. Dyck et al.: Anesthesiology 78:821-828, 1993"]
[]
[]
[]
["Revision history"]
[null,null,null,"Rev.","Description",null,null,null,"ORG","CHK","APP","Date (dd/mm/yy)"]
[null,null,null,1,"Release",null,null,null,"TDS",null,null,"2004-01-31"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Procedure:",null,"* Fill in the yellow-colored boxes with your patient's weight, age,… "]
[]
[]
[null,null,"* Fill in the orange boxes with the Time, infused volume, cp & ce series from your RGL file for remifentanil. You can use either the time column in 25ms units (RGLII format) or the time column. Only the latter one will be used, and contains by default the formula to calculate the time from the first column."]
[]
[]
[null,null,"* The time intervals do not have to be constant. The only relevant thing is that the time entered and the infused volume entered match. E.g. : Time 0s -> infused volume 0ml ; T = 10s-> infused volume 1.5ml; T = 15s -> infused volume 2ml; … The spreadsheet will recalculate the corresponding infusion rates to get Cp & Ce"]
[]
[]
[null,null,"* Important remark: when entering time, … data, make sure to leave the first row (which is read-only) and that your first entered line has infused volume zero. This will give the correct offset; otherwise, the first interval will not be correct, and the calculations will be wrong as well."]
[]
[]
[null,null,"* The spreadsheet will calculate the realised Cp & Ce values at the entered time, using the model specified. Use the columns Cp, calculated & Ce, calculated to read the calculated Cp & Ce for this specific model.                                                                                                                     "]
[]
[]
[null,null,"* if you also have the already calculated Cp & Ce but, for example, if you wanted to verify two different models for the same drug, you can enter them as well in the specified orange columns for Cp & Ce. The spreadsheet will then immedicately give you the procentual difference between your own calculations & the results calculated by this model in the green columns.   "]
[]
[]
[null,null,"* the fields input table, root calculation, Pcoeff calculation, Root verification & Modelling results are only for information. "]
[]
[]
[]
[]
["Model:",null,"Unit of concentration : ng/ml"]
[]
[null,null,"Vc = 7.99l"]
[null,null,"V2 = 13.8l"]
[null,null,"V3 = 187 l"]
[null,null,"Cl1 = 0.00791*height-0.927"]
[null,null,"Cl2 = 2.26l/min"]
[null,null,"Cl3 = 1.99l/min"]
[]
[]
["Patient data"]
[]
["Enter patient age",null,null,null,null,{"$f":"OFA!E14","v":40},"years"]
["Enter patient weight ",null,null,null,null,71,"kg"]
["Enter patient height ",null,null,null,null,{"$f":"OFA!E18","v":160},"cm"]
["Enter patient gender ",null,null,null,null,{"$f":"OFA!E22","v":2},"(1 = MALE, 2 = FEMALE)"]
["Enter drug conc",null,null,null,null,{"$f":"OFA!Concentration_Sufenta","v":10},"µg/ml"]
[]
["Model covariates",null,null,null,null,null,"------>",null,null,"Model K-values"]
[null,null,null,null,"Male","Female",null,null,null,null,0.5]
["Lbm",null,{"$f":"IF((F73=1),E78,IF((F73=2),F78,1/0))","v":46.826718749999998},null,{"$f":"1.1*F71-128*F71/F72*F71/F72","v":52.89500000000001},{"$f":"1.07*F71-148*F71/F72*F71/F72","v":46.826718749999998},null,"Vc",{"$f":"7.99","v":7.99},"Vc",{"$f":"I78","v":7.99}]
["BSA",null,{"$f":"POWER(F71,0.425)*POWER(F72,0.725)*0.007184","v":1.7423608706800495},null,null,null,null,"V2",{"$f":"13.8","v":13.8},"K10",{"$f":"I81/I78","v":4.2377972465581976E-2},"1/min"]
[null,null,null,null,null,null,null,"V3",187,"K12",{"$f":"I82/I78","v":0.28285356695869834},"1/min"]
[null,null,null,null,null,null,null,"Cl1",{"$f":"0.00791*F72-0.927","v":0.33860000000000001},"K13",{"$f":"I83/I78","v":0.2490613266583229},"1/min"]
[null,null,null,null,null,null,null,"Cl2",2.2599999999999998,"K21",{"$f":"I82/I79","v":0.16376811594202897},"1/min"]
[null,null,null,null,null,null,null,"Cl3",1.99,"K31",{"$f":"I83/I80","v":1.0641711229946524E-2},"1/min"]
[null,null,null,null,null,null,null,null,null,"K41",0,"1/min"]
[]
["Tpeak",null,0,"min"]
["Drug conc[µg/ml]",null,{"$f":"F74","v":10}]
[]
["Input table",null,null,null,"Root calculation",null,null,null,null,null,null,"Pcoeff calculation",null,null,null,null,"K41 determinations - estimate for tpeak. "]
[null,null,null,"Value","K31>0","K21>0","Else",null,"K31>0","K21>0","Else",null,"K31>0","K21>0","Else"]
["Vc",null,{"$f":"K78","v":7.99},"a0",{"$f":"D_K10*D_K21*D_K31","v":3.4192215808035668E-10},{"$f":"D_K10*D_K21","v":1.9278224189254282E-6},"_","PCoef1",{"$f":"(D_K21-D_Lambda1)*(D_K31-D_Lambda1)/(D_Lambda1-D_Lambda2)/(D_Lambda1-D_Lambda3)/D_Vc/D_Lambda1","v":9.4447766487277178},{"$f":"(D_K21-D_Lambda1)/(D_Lambda2-D_Lambda1)/D_Vc/D_Lambda1","v":9.5768452611807202},{"$f":"1/D_Vc/D_Lambda1","v":11.210621214250793},"ECoef1",{"$f":"D_PCoef1/(D_K41-D_Lambda1)*D_K41","v":0},{"$f":"J91/(D_K41-D_Lambda1)*D_K41","v":0},{"$f":"K91/(D_K41-D_Lambda1)*D_K41","v":0},null,"Table calculating dirac-impulse concentration result at time tpeak for a certain set of Kvalues"]
["K10",null,{"$f":"K79/60","v":7.0629954109303298E-4},"a1",{"$f":"D_K10*D_K31+D_K21*D_K31+D_K21*D_K13+D_K10*D_K21+D_K31*D_K12","v":1.4703405014705265E-5},{"$f":"(D_K10+D_K12+D_K21)","v":8.1499942561051551E-3},"_","PCoef2",{"$f":"(D_K21-D_Lambda2)*(D_K31-D_Lambda2)/(D_Lambda2-D_Lambda1)/(D_Lambda2-D_Lambda3)/D_Vc/D_Lambda2","v":12.419243333183427},{"$f":"(D_K21-D_Lambda2)/(D_Lambda1-D_Lambda2)/D_Vc/D_Lambda2","v":14.13321115990183},0,"ECoef2",{"$f":"D_PCoef2/(D_K41-D_Lambda2)*D_K41","v":0},{"$f":"J92/(D_K41-D_Lambda2)*D_K41","v":0},0,null,"When the results Ceff have a peak it is what we want. "]
["K12",null,4.7142261159783061E-3,"a2",{"$f":"D_K10+D_K12+D_K13+D_K31+D_K21","v":1.2478378220909645E-2},"_","_","PCoef3",{"$f":"(D_K21-D_Lambda3)*(D_K31-D_Lambda3)/(D_Lambda3-D_Lambda2)/(D_Lambda3-D_Lambda1)/D_Vc/D_Lambda3","v":155.33621628506822},0,0,"ECoef3",{"$f":"D_PCoef3/(D_K41-D_Lambda3)*D_K41","v":0},0,0,null,"If the values keep increasing, k41 must increase."]
["K13",null,4.1510221109720483E-3,"p",{"$f":"D_a1-(D_a2*D_a2/3)","v":-3.7199902659985455E-5},"_","_",null,null,null,null,"ECoef4",{"$f":"(D_K41-D_K21)*(D_K41-D_K31)/(D_Lambda1-D_K41)/(D_Lambda2-D_K41)/(D_Lambda3-D_K41)/D_Vc","v":177.20023626697935},{"$f":"(D_K21-D_K41)/(D_Lambda1-D_K41)/(D_Lambda2-D_K41)/D_Vc","v":23.710056421082548},{"$f":"1/(D_Lambda1-D_K41)/D_Vc","v":11.210621214250791},null,"If the values keep decreasing, k41 must decrease."]
["K21",null,2.7294685990338161E-3,"q",{"$f":"(2*D_a2*D_a2*D_a2/27)-(D_a1*D_a2/3)+D_a0_2","v":8.3110173428739332E-8},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,"E1'","E2'","E3'","E4'"]
["K31",null,1.7736185383244207E-4,"r1",{"$f":"SQRT(-(D_p*D_p*D_p)/27)","v":4.3664734432245514E-8},"_","_",null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D_ECoef1*D_Lambda1","v":0},{"$f":"D_ECoef2*D_Lambda2","v":0},{"$f":"D_ECoef3*D_Lambda3","v":0},{"$f":"D_ECoef4*D_Lambda4","v":0}]
["K41",null,0,null,{"$f":"(MIN(MAX(-D_q/2/D_r1,-1),1))","v":-0.95168531893513786},null,null,null,null,"Modelling results ",null,null,null,null,null,null,null,null,"Ceff","I1'","I2'","I3'","I4'"]
[null,null,null,"Phi",{"$f":"(ACOS(MIN(MAX((-D_q/2)/D_r1,-1),1)))/3","v":0.94315821656667753},"_","_",null,null,"Lambda1",{"$f":"IF(D_K31>0,E103,IF(D_K21>0,F103,G103))","v":1.1164095473839486E-2},null,null,null,null,null,"T1",{"$f":"C86*60*0.99","v":0},{"$f":"T98*$T$96+U98*$U$96+V98*$V$96+W98*$W$96","v":0},{"$f":"EXP(-D_Lambda1*$R$98)","v":1},{"$f":"EXP(-D_Lambda2*$R$98)","v":1},{"$f":"EXP(-D_Lambda3*$R$98)","v":1},{"$f":"EXP(-D_Lambda4*$R$98)","v":1}]
["Root verification",null,null,"r1_Use",{"$f":"2*EXP(LN(D_r1)/3)","v":7.04271753042204E-3},"_","_",null,null,"Lambda2",{"$f":"IF(D_K31>0,E104,IF(D_K21>0,F104,G104))","v":1.2905510656124708E-3},null,null,null,null,null,"T2",{"$f":"C86*60","v":0},{"$f":"T99*$T$96+U99*$U$96+V99*$V$96+W99*$W$96","v":0},{"$f":"EXP(-D_Lambda1*$R$99)","v":1},{"$f":"EXP(-D_Lambda2*$R$99)","v":1},{"$f":"EXP(-D_Lambda3*$R$99)","v":1},{"$f":"EXP(-D_Lambda4*$R$99)","v":1}]
["L1",{"$f":"(POWER(-E100,3)+POWER(E100,2)*D_a2-E100*D_a1+D_a0_2)<0.000000000000001","v":true},{"$f":"POWER(F100,2)-D__a1*F100+D__a0","v":0},"L1",{"$f":"-(COS(D_Phi)*D_r1_Use-D_a2/3)","v":2.3731681457687948E-5},{"$f":"-(-D__a1+SQRT(D__a1*D__a1-4*D__a0))/2","v":2.4383814222187633E-4},{"$f":"D_K10","v":7.0629954109303298E-4},null,null,"Lambda3",{"$f":"IF(D_K31>0,E105,IF(D_K21>0,F105,G105))","v":2.3731681457687948E-5},null,null,null,null,null,"T3",{"$f":"C86*60*1.01","v":0},{"$f":"T100*$T$96+U100*$U$96+V100*$V$96+W100*$W$96","v":0},{"$f":"EXP(-D_Lambda1*$R$100)","v":1},{"$f":"EXP(-D_Lambda2*$R$100)","v":1},{"$f":"EXP(-D_Lambda3*$R$100)","v":1},{"$f":"EXP(-D_Lambda4*$R$100)","v":1}]
["L2",{"$f":"(POWER(-E101,3)+POWER(E101,2)*D_a2-E101*D_a1+D_a0_2)<0.000000000000001","v":true},{"$f":"POWER(F101,2)-F101*D__a1+D__a0","v":0},"L2",{"$f":"-(COS(D_Phi+PI()*2/3)*D_r1_Use-D_a2/3)","v":1.1164095473839486E-2},{"$f":"-(-D__a1-SQRT(D__a1*D__a1-4*D__a0))/2","v":7.9061561138832788E-3},0,null,null,"Lambda4",{"$f":"D_K41","v":0}]
["L3",{"$f":"(POWER(-E102,3)+POWER(E102,2)*D_a2-E102*D_a1+D_a0_2)<0.000000000000001","v":true},null,"L3",{"$f":"-(COS(D_Phi+PI()*4/3)*D_r1_Use-D_a2/3)","v":1.2905510656124708E-3},0,0,null,null,"PCoef1",{"$f":"IF(D_K31>0,I91,IF(D_K21>0,J91,K91))","v":9.4447766487277178}]
[null,null,null,"L1_SORT",{"$f":"MAX(MAX(E100,E101),E102)","v":1.1164095473839486E-2},{"$f":"MAX(MAX(F100,F101),F102)","v":7.9061561138832788E-3},{"$f":"MAX(MAX(G100,G101),G102)","v":7.0629954109303298E-4},null,null,"PCoef2",{"$f":"IF(D_K31>0,I92,IF(D_K21>0,J92,K92))","v":12.419243333183427},null,null,null,null,null,null,null,null,null,null,"Colonne des zéros"]
[null,null,null,"L2_SORT",{"$f":"IF(AND(E103<>E100,E105<>E100),E100,IF(AND(E103<>E101,E105<>E101),E101,E102))","v":1.2905510656124708E-3},{"$f":"IF(AND(F103<>F100,F105<>F100),F100,IF(AND(F103<>F101,F105<>F101),F101,F102))","v":2.4383814222187633E-4},{"$f":"IF(AND(G103<>G100,G105<>G100),G100,IF(AND(G103<>G101,G105<>G101),G101,G102))","v":0},null,null,"PCoef3",{"$f":"IF(D_K31>0,I93,IF(D_K21>0,J93,K93))","v":155.33621628506822}]
[null,null,null,"L3_SORT",{"$f":"MIN(MIN(E100,E101),E102)","v":2.3731681457687948E-5},{"$f":"MIN(MIN(F100,F101),F102)","v":0},{"$f":"MIN(MIN(G100,G101),G102)","v":0},null,null,"ECoef1",{"$f":"IF(D_K31>0,M91,IF(D_K21>0,N91,O91))","v":0},null,null,null,null,null,null,null,null,null,null,"Colonne liée à la première ligne de formules","chaque = est fait cellule a cellule pour la ligne verte"]
[null,null,null,null,null,null,null,null,null,"ECoef2",{"$f":"IF(D_K31>0,M92,IF(D_K21>0,N92,O92))","v":0}]
[null,null,null,null,null,null,null,null,null,"ECoef3",{"$f":"IF(D_K31>0,M93,IF(D_K21>0,N93,O93))","v":0},null,null,null,null,null,null,null,null,null,null,"colonne bleue: c'est un copié collé spécial transposé des formules"]
[null,null,null,null,null,null,null,null,null,"ECoef4",{"$f":"IF(D_K31>0,M94,IF(D_K21>0,N94,O94))","v":177.20023626697935}]
[]
["Time","Time ","Infused volume","Cp, calculated","Ce,calculated","DeltaTime","InfusionRate","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time","25ms",0,5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180,185,190,195,200,205,210,215,220,225,230,235,240,245,250,255,260,265,270,275,280,285,290,295,300]
["MIN","s","mls","ng/ml","ng/ml","DeltaTime,s","InfusionRate, amt/s","I1","I2","I3","I4","PState1","PState2","PState3","eState1","eState2","eState3","eState4",null,"Time ","s",0,{"$f":"W110*60","v":300},{"$f":"X110*60","v":600},{"$f":"Y110*60","v":900},1200,1500,1800,2100,2400,2700,3000,3300,3600,3900,4200,4500,4800,5100,5400,5700,6000,6300,6600,6900,7200,7500,7800,8100,8400,8700,9000,9300,9600,9900,10200,10500,10800,11100,11400,11700,12000,12300,12600,12900,13200,13500,13800,14100,14400,14700,15000,15300,15600,15900,16200,16500,16800,17100,17400,17700,18000]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Infused volume","mls",0,{"$f":"C114","v":0},{"$f":"OFA!L43","v":0},{"$f":"OFA!M43","v":0},{"$f":"OFA!N43","v":0},{"$f":"OFA!O43","v":0},{"$f":"OFA!P43","v":0},{"$f":"OFA!Q43","v":0},{"$f":"OFA!R43","v":0},{"$f":"OFA!S43","v":0},{"$f":"OFA!T43","v":0},{"$f":"OFA!U43","v":0},{"$f":"OFA!V43","v":0},{"$f":"OFA!W43","v":0},{"$f":"OFA!X43","v":0},{"$f":"OFA!Y43","v":0},{"$f":"OFA!Z43","v":0},{"$f":"OFA!AA43","v":0},{"$f":"OFA!AB43","v":0},{"$f":"OFA!AC43","v":0},{"$f":"OFA!AD43","v":0},{"$f":"OFA!AE43","v":0},{"$f":"OFA!AF43","v":0},{"$f":"OFA!AG43","v":0},{"$f":"OFA!AH43","v":0},{"$f":"OFA!AI43","v":0},{"$f":"OFA!AJ43","v":0},{"$f":"OFA!AK43","v":0},{"$f":"OFA!AL43","v":0},{"$f":"OFA!AM43","v":0},{"$f":"OFA!AN43","v":0},{"$f":"OFA!AO43","v":0},{"$f":"OFA!AP43","v":0},{"$f":"OFA!AQ43","v":0},{"$f":"OFA!AR43","v":0},{"$f":"OFA!AS43","v":0},{"$f":"OFA!AT43","v":0},{"$f":"OFA!AU43","v":0},{"$f":"OFA!AV43","v":0},{"$f":"OFA!AW43","v":0},{"$f":"OFA!AX43","v":0},{"$f":"OFA!AY43","v":0},{"$f":"OFA!AZ43","v":0},{"$f":"OFA!BA43","v":0},{"$f":"OFA!BB43","v":0},{"$f":"OFA!BC43","v":0},{"$f":"OFA!BD43","v":0},{"$f":"OFA!BE43","v":0},{"$f":"OFA!BF43","v":0},{"$f":"OFA!BG43","v":0},{"$f":"OFA!BH43","v":0},{"$f":"OFA!BI43","v":0},{"$f":"OFA!BJ43","v":0},{"$f":"OFA!BK43","v":0},{"$f":"OFA!BL43","v":0},{"$f":"OFA!BM43","v":0},{"$f":"OFA!BN43","v":0},{"$f":"OFA!BO43","v":0},{"$f":"OFA!BP43","v":0},{"$f":"OFA!BQ43","v":0},{"$f":"OFA!BR43","v":0}]
[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,"Cp, calculated","ng/ml",0,{"$f":"D114","v":0},{"$f":"X121+X122+X123","v":0},{"$f":"Y121+Y122+Y123","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[5,{"$f":"A114*60","v":300},{"$f":"OFA!K43","v":0},{"$f":"L114+M114+N114","v":0},{"$f":"O114+P114+Q114+R114","v":0},{"$f":"B114-B113","v":300},{"$f":"IF(F114>0,(C114-C113)/F114*$C$87,#N/A)","v":0},{"$f":"EXP(-D_Lambda1*$F114)","v":3.5111427132883656E-2},{"$f":"EXP(-D_Lambda2*$F114)","v":0.67897883708106344},{"$f":"EXP(-D_Lambda3*$F114)","v":0.99290577919651368},{"$f":"EXP(-D_Lambda4*$F114)","v":1},{"$f":"L113*H114+(1-H114)*$G114*D_PCoef1","v":0},{"$f":"M113*I114+(1-I114)*$G114*D_PCoef2","v":0},{"$f":"N113*J114+(1-J114)*$G114*D_PCoef3","v":0},{"$f":"O113*H114+(1-H114)*$G114*D_ECoef1","v":0},{"$f":"P113*I114+(1-I114)*$G114*D_ECoef2","v":0},{"$f":"Q113*J114+(1-J114)*$G114*D_ECoef3","v":0},{"$f":"R113*K114+(1-K114)*$G114*D_ECoef4","v":0},null,"Ce,calculated","ng/ml",0,{"$f":"E114","v":0},{"$f":"X124+X125+X126+X127","v":0},{"$f":"Y124+Y125+Y126+Y127","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[10,600,null,0,0,{"$f":"B115-B114","v":300},{"$f":"IF(F115>0,(C115-C114)/F115*$C$87,#N/A)","v":0},3.5111427132883656E-2,0.67897883708106344,0.99290577919651368,1,0,0,0,0,0,0,0,null,"DeltaTime","DeltaTime,s",0,{"$f":"F114","v":300},{"$f":"X111-W111","v":300},{"$f":"Y111-X111","v":300},300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300,300]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"InfusionRate","InfusionRate, amt/s",0,{"$f":"G114","v":0},{"$f":"IF(X115>0,(X112-W112)/X115*$C$87,#N/A)","v":0},{"$f":"IF(Y115>0,(Y112-X112)/Y115*$C$87,#N/A)","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
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{"sheet":"LIDO","index":14,"n_rows":74,"n_cols":67,"rows_kept":74,"cut":false,"hidden":true,"merged":[]}
[null,null,null,null,"avec la formule de la ligne 9, un collage spécial des formules transposé sur la colonne E marche !",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Ainsi pour chaque bolus, le temps est remis à zéro cat t = t(ligne7) - t (colonne F)"]
[null,null,null,null,"Il faudrait programmer une boucle dans VBA, qui remette le temps à zéro à chaque fois que q <> zéro"]
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{"sheet":"YourDrug","index":15,"n_rows":74,"n_cols":67,"rows_kept":74,"cut":false,"hidden":true,"merged":[[8,1,8,2],[9,1,9,2],[1,1,1,3]]}
[null,null,null,null,"avec la formule de la ligne 9, un collage spécial des formules transposé sur la colonne E marche !",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Ainsi pour chaque bolus, le temps est remis à zéro cat t = t(ligne7) - t (colonne F)"]
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